α-synuclein Ligand
-
Pittsburgh Compound B
0 ImagesSynonyms: PiB; 6-OH-BTA-1Pittsburgh Compound B (PiB) is a blood-brain barrier-permeable, specific Aβ deposition PET tracer that binds to Aβ(1-40) fibrils with a Ki value of 678.4 nM. Through click chemical modification (a clickable Pittsburgh Compound B derivative is prepared by introducing a PEG3 linker and an alkynyl group at the 6-hydroxy site of Pittsburgh Compound B, followed by covalent conjugation with azide-labeled fluorescent dyes or affinity tags via copper-catalyzed azide-alkyne cycloaddition (CuAAC)), Pittsburgh Compound B and its conjugates can be used for fluorescence imaging, ultrastructural studies, and enrichment and characterization of Aβ complexes. Pittsburgh Compound B is applicable to Alzheimer's disease research.
-
MK-7337
0 ImagesMK-7337 is an α-synuclein ligand with an affinity of < 1 nM. MK-7337 labeled with 11C can be used as a PET tracer for neurodegenerative disorders like Parkinson’s disease imagination.
-
α-Synuclein ligand-1
0 ImagesCat. No.: HY-187000CAS No.: 749927-21-7α-Synuclein ligand-1 is a α-Synuclein ligand, which can be used for the synthesis of PROTACs, such as PROTAC α-synuclein degrader 5 (HY-155021).
-
KAC-50.1
0 ImagesCat. No.: HY-168647KAC-50.1 is an α-Synuclein (α-syn) PET ligand, with a KD of 35 nM toward site 2 in recombinant α-syn fibrils.
