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Cat. No.: HY-168647

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KAC-50.1

KAC-50.1 is an α-Synuclein (α-syn) PET ligand, with a K_D of 35 nM toward site 2 in recombinant α-syn fibrils.

For research use only. We do not sell to patients.

Formula: C₁₇H₁₅N₃O
Molecular Weight:277.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

KAC-50.1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Hot Topics (1)
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

KAC-50.1 is an α-Synuclein (α-syn) PET ligand, with a K_D of 35 nM toward site 2 in recombinant α-syn fibrils^[1].

IC₅₀ & Target

α-synuclein

All α-synuclein Isoforms :

Chemical Information

Molecular Weight 277.32
Formula C₁₇H₁₅N₃O
SMILES

COC1=CC=C(C=C1)/C=C/C2=CN(N=N2)C3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dinahlee Saturnino Guarino, et al. Identification and In Vitro and In Vivo Characterization of KAC-50.1 as a Potential α-Synuclein PET Radioligand. ACS Chem Neurosci. 2024 Nov 20;15(22):4210-4219. [Content Brief]

Hot Topics

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Topics Synaptic Plasticity & Brain Health
Synaptic plasticity is the activity-, experience-, development-, and injury-dependent modification of synaptic strength, number, and structure, and it remains a central mechanism for learning, memory, sensory adaptation, and brain health.

2026-06-18

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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KAC-50.1

All α-synuclein Isoforms

Biological Activity

Description

IC50 & Target

Chemical Information

Purity & Documentation

References

Hot Topics

Calculators

Help & FAQs

KAC-50.1 Related Classifications

HY-168647 Related Classifications

Bioz

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