Terbutryn

Cat. No.: HY-B1991 Pureza: 98.10%: Ficha de datos
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Terbutryn is a photosystem II inhibitor and aquatic toxicant. Terbutryn interferes with photosynthesis by inhibiting photosystem II. Terbutryn reduces the production of periphyton by acting directly on periphytic algae in artificial indoor streams. Terbutryn reduces the population growth of Lumbriculus variegatus in artificial indoor streams through indirect effects associated with the reduction of food sources for periphyton. The overall 50% dissipation time (DT₅₀) of Terbutryn in the water of artificial indoor streams is 28 d.

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Terbutryn Estructura química

No. CAS : 886-50-0

Tamaño	Stock	Cantidad

Muestra gratis (0.1 - 0.2 mg)	Solicite ahora
Muestra gratis (0.1 - 0.2 mg)	Solicite ahora
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
500 mg	En stock	Estimated Time of Arrival: December 31
1 g	Obtener un presupuesto
5 g	Obtener un presupuesto

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This product is a controlled substance and not for sale in your territory.

Other Forms of Terbutryn:

Terbutryn-d₅ Obtener un presupuesto
Terbutryn (Standard) Obtener un presupuesto

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Descripciòn

In Vivo

Terbutryn exhibits toxicity to Lumbriculus variegatus in static acute toxicity tests. Lethal effects include lysis, cessation of blood circulation and coelomic fluid extravasation, while sublethal effects include deformation and autotomy.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

241.36

Fòrmula

C₁₀H₁₉N₅S

No. CAS

886-50-0

Appearance

Solid

Color

White to off-white

SMILES

CSC1=NC(NC(C)(C)C)=NC(NCC)=N1

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvente y solubilidad

In Vitro:

DMSO : ≥ 100 mg/mL (414.32 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1432 mL	20.7159 mL	41.4319 mL
5 mM	0.8286 mL	4.1432 mL	8.2864 mL
10 mM	0.4143 mL	2.0716 mL	4.1432 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (10.36 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (10.36 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Pureza y Documentación

Purity: 98.10%

Select Batch:

Ficha de datos (270 KB) SDS (459 KB)

COA (246 KB) LCMS (105 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Brust K, et al. Effects of terbutryn on aufwuchs and Lumbriculus variegatus in artificial indoor streams. Environ Toxicol Chem. 2001;20(9):2000-2007. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.1432 mL	20.7159 mL	41.4319 mL	103.5797 mL
	5 mM	0.8286 mL	4.1432 mL	8.2864 mL	20.7159 mL
	10 mM	0.4143 mL	2.0716 mL	4.1432 mL	10.3580 mL
	15 mM	0.2762 mL	1.3811 mL	2.7621 mL	6.9053 mL
	20 mM	0.2072 mL	1.0358 mL	2.0716 mL	5.1790 mL
	25 mM	0.1657 mL	0.8286 mL	1.6573 mL	4.1432 mL
	30 mM	0.1381 mL	0.6905 mL	1.3811 mL	3.4527 mL
	40 mM	0.1036 mL	0.5179 mL	1.0358 mL	2.5895 mL
	50 mM	0.0829 mL	0.4143 mL	0.8286 mL	2.0716 mL
	60 mM	0.0691 mL	0.3453 mL	0.6905 mL	1.7263 mL
	80 mM	0.0518 mL	0.2589 mL	0.5179 mL	1.2947 mL
	100 mM	0.0414 mL	0.2072 mL	0.4143 mL	1.0358 mL

Terbutryn Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Terbutryn886-50-0Environmental PollutantsHerbicideEnvironmental ContaminantsaufwuchsLumbriculus variegatusPhotosystem IIphotosynthesisperiphytonaquatic toxicantInhibitorinhibitorinhibit

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Terbutryn

Other Forms of Terbutryn:

Terbutryn Related Antibodies

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