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Cat. No.: HY-P3683

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a-Helical Corticotropin Releasing Factor (12-41)

a-Helical Corticotropin Releasing Factor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect.

For research use only. We do not sell to patients.

CAS No.: 158535-55-8
Formula: C₁₅₂H₂₅₁N₄₃O₄₇S₂
Molecular Weight:3497.01

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

a-Helical Corticotropin Releasing Factor (12-41) Chemical Structure

CAS No.: 158535-55-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All CRFR Isoforms :

CRFR1
CRFR2

In Vitro

a-Helical Corticotropin Releasing Factor (0.3 nM; 5-min pulses every 40 min alternately) shows the inhibitory effect on stimulated release of immunoreactive ACTH from perifused equine anterior pituitary cells in vitro.^[2].
a-Helical Corticotropin Releasing Factor (0.5-5 μM) suppresses CRH-induced ACTH secretion^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

a-Helical Corticotropin Releasing Factor (12-41) (15-150 μg; s.c.; isolated for 30 or 60 min) suppresses the active behavioral response characteristic of guinea pig pups to brief isolation in novel surroundings^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Guinea pig pups (20-26 days old and )^[1]
Dosage:

15, 50, 150 μg per animal
Administration:

Subcutaneous injection; isolated in novel surroundings for 30 min or 60 min.
Result:

Resulted pups vocalized more and exhibited more locomotor activity in 20- to 26-day-old pups.
Increased levels of vocalizing in isolated 4- to 6-day-old pups at 50 μg dose, though no changes were seen in locomotor activity.

Chemical Information

CAS No. 158535-55-8
Molecular Weight 3497.01
Formula C₁₅₂H₂₅₁N₄₃O₄₇S₂
Sequence Shortening

FHLLREMLEMAKAEQEAEQAALNRLLLEEA-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hennessy MB, et al. Evidence that endogenous corticotropin-releasing factor suppresses behavioral responses of guinea pig pups to brief isolation in novel surroundings. Dev Psychobiol. 1997 Jul;31(1):39-47. [Content Brief]

[2]. Ellis M J, et al. The effects of corticotrophin-releasing hormone, arginine vasopressin and their antagonists on ACTH release from perifused horse anterior pituitary cells[J]. Journal of endocrinology, 1994, 143(1): 85-93.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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a-Helical Corticotropin Releasing Factor (12-41)

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Biological Activity
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- In Vivo
Chemical Information
Purity & Documentation
References

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a-Helical Corticotropin Releasing Factor (12-41)

All CRFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

a-Helical Corticotropin Releasing Factor (12-41) Related Classifications

HY-P3683 Related Classifications

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