2. GPCR/G Protein
  3. CRFR
  4. a-Helical Corticotropin Releasing Factor (12-41)

a-Helical Corticotropin Releasing Factor (12-41) 

Cat. No.: HY-P3683
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a-Helical Corticotropin Releasing Factor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect.

For research use only. We do not sell to patients.

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a-Helical Corticotropin Releasing Factor (12-41) Chemical Structure

a-Helical Corticotropin Releasing Factor (12-41) Chemical Structure

CAS No. : 158535-55-8

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a-Helical Corticotropin Releasing Factor (12-41) Related Antibodies

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Description

a-Helical Corticotropin Releasing Factor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect[1][2].

In Vitro

a-Helical Corticotropin Releasing Factor (0.3 nM; 5-min pulses every 40 min alternately) shows the inhibitory effect on stimulated release of immunoreactive ACTH from perifused equine anterior pituitary cells in vitro.[2].
a-Helical Corticotropin Releasing Factor (0.5-5 μM) suppresses CRH-induced ACTH secretion[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

a-Helical Corticotropin Releasing Factor (12-41) Related Antibodies
In Vivo

a-Helical Corticotropin Releasing Factor (12-41) (15-150 μg; s.c.; isolated for 30 or 60 min) suppresses the active behavioral response characteristic of guinea pig pups to brief isolation in novel surroundings[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Guinea pig pups (20-26 days old and )[1]
Dosage: 15, 50, 150 μg per animal
Administration: Subcutaneous injection; isolated in novel surroundings for 30 min or 60 min.
Result: Resulted pups vocalized more and exhibited more locomotor activity in 20- to 26-day-old pups.
Increased levels of vocalizing in isolated 4- to 6-day-old pups at 50 μg dose, though no changes were seen in locomotor activity.
Molecular Weight

3497.01

Formula

C152H251N43O47S2
CAS No.
Sequence Shortening

FHLLREMLEMAKAEQEAEQAALNRLLLEEA-NH2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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a-Helical Corticotropin Releasing Factor (12-41) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

a-Helical Corticotropin Releasing Factor (12-41)158535-55-8CRFRCorticotropin-releasing Factor ReceptorCRHRhypothalamic hormoneadrenocorticotrophic hormoneACTHCRFCRHInhibitorinhibitorinhibit

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