Aldose reductase-IN-10
Aldose reductase-IN-10 is an inhibitor of aldose reductase with an IC50 of 1.965 μM. Aldose reductase-IN-10 reduces malondialdehyde levels and enhances the activities of SOD, CAT and GPx. Aldose reductase-IN-10 decreases total cholesterol, triglyceride and LDL-C levels, while increasing HDL-C levels. Aldose reductase-IN-10 can be used for the research of diabetic complications.
For research use only. We do not sell to patients.
- Formula: C17H17N5O2S
- Molecular Weight:355.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss albino (male, 25-30 g, streptozotocin-induced diabetes mellitus)[1]
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Dosage:10 mg/kg
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Administration:i.p.; daily; 15 days
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Result:Reduced malondialdehyde levels by 37% relative to untreated diabetic mice.
Increased superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities by 72%, 97%, and 52% respectively, relative to untreated diabetic mice.
Decreased total cholesterol (TC) by 40%, triglycerides (TG) by 42%, and LDL-C by 49%, while increasing HDL-C, relative to untreated diabetic mice.
Reduced serum AST by 32%, ALT by 55%, and total bilirubin by 47%, while increasing albumin levels by 31%, relative to untreated diabetic mice.
Reduced serum creatinine by 26% and blood urea nitrogen (BUN) by 48%, relative to untreated diabetic mice.
Reduced fasting blood glucose by 53% relative to untreated diabetic mice.
Mitigated liver damage (reduced inflammation, hydropic degeneration, and steatosis) and kidney damage (reduced glomerular congestion, tubular dilation, and inflammatory infiltration) relative to untreated diabetic mice.
Chemical Information
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Molecular Weight 355.41
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Formula C17H17N5O2S
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SMILES
CC(C(S1)=C(C)N=C1N/N=C(C)/C2=CC=C(NC(CC#N)=O)C=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aldose reductase-IN-10 Related Classifications
HY-184702 Related Classifications
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