Ammonium lactate (60%w/w in water)
Based on 45 publication(s) in Google Scholar
Ammonium lactate is the ammonium salt of lactic acid, with mild anti-bacterial properties. Ammonium lactate can be used for the research of xerosis.
For research use only. We do not sell to patients.
- CAS No.: 515-98-0
- Formula: C3H9NO3
- Molecular Weight:107.11
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Storage:
Solution, -20°C, 2 years
Publications Citing Use of MedChemExpress (MCE) Ammonium lactate (60%w/w in water)
More- Bioact Mater. 2024 Jun 24:40:445-459. [Abstract]
- Nat Commun. 2025 Dec 12. [Abstract]
- J Adv Res. 2025 May 13:S2090-1232(25)00351-0. [Abstract]
- Redox Biol. 2025 Apr:81:103553. [Abstract]
- Acta Pharm Sin B. 2026 Feb.
- MedComm (2020). 2025 Aug 29;6(9):e70344. [Abstract]
- Adv Sci (Weinh). 2025 Jul 29:e09477. [Abstract]
- Adv Sci (Weinh). 2024 May 20:e2307216. [Abstract]
- Cell Death Differ. 2025 Sep 23. [Abstract]
- Research (Wash D C). 2025 May 30:8:0705. [Abstract]
- Cell Death Dis. 2025 Feb 28;16(1):144. [Abstract]
- Int J Biol Sci. 2025 Apr 22;21(7):3061-3080. [Abstract]
- Clin Cancer Res. 2026 Apr 17. [Abstract]
- J Transl Med. 2025 Aug 18;23(1):923. [Abstract]
- Cell Rep. 2025 Jul 30;44(8):116091. [Abstract]
- J Ginseng Res. 2024 May;48(3):298-309. [Abstract]
- J Agric Food Chem. 2026 Jun 24;74(24):18768-18778. [Abstract]
- J Agric Food Chem. 2025 Dec 17;73(50):32236-32249. [Abstract]
- Ecotoxicol Environ Saf. 2025 Nov 15:307:119451. [Abstract]
- Biochem Pharmacol. 2026 Mar 20:249:117918. [Abstract]
- RSC Adv. 2026 May 18;16(21):19511-19523. [Abstract]
- Cancer Metab. 2026 Apr 2;14(1):13. [Abstract]
- Commun Biol. 2025 Nov 20;8(1):1626. [Abstract]
- Commun Biol. 2025 Jul 8;8(1):1020. [Abstract]
- Cancer Immunol Immunother. 2024 Oct 3;73(12):254. [Abstract]
- Respir Res. 2024 Nov 9;25(1):401. [Abstract]
- Sci Rep. 2026 May 25. [Abstract]
- Food Qual Saf. 2025 Aug 4.
- Cell Signal. 2026 Jun 27:112701. [Abstract]
- J Cell Mol Med. 2025 Jul;29(13):e70692. [Abstract]
- J Cell Mol Med. 2025 Jun;29(12):e70669. [Abstract]
- Brain Res Bull. 2025 May:224:111292. [Abstract]
- FASEB J. 2026 May 15;40(9):e71765. [Abstract]
- FASEB J. 2026 Feb 15;40(3):e71547. [Abstract]
- Ren Fail. 2026 Dec;48(1):2630507. [Abstract]
- Vet Res. 2025 Apr 30;56(1):94. [Abstract]
- J Integr Neurosci. 2025 Feb 25;24(2):25949. [Abstract]
- Exp Eye Res. 2026 Jun:267:110981. [Abstract]
- Kaohsiung J Med Sci. 2025 Nov 13:e70123. [Abstract]
- Tissue Cell. 2024 Jul 9:89:102468. [Abstract]
- J Cardiovasc Transl Res. 2025 Sep 8. [Abstract]
- Biochem Biophys Res Commun. 2025 Sep 8:778:152379. [Abstract]
- Genes Genomics. 2025 May;47(5):521-531. [Abstract]
- Res Sq. 2026 Jun 15.
- bioRxiv. 2026 Mar 10.
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WB
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WB
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RT-PCR
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IP
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RT-PCR
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 515-98-0
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Appearance Liquid
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Molecular Weight 107.11
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Formula C3H9NO3
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Color Colorless to light yellow
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SMILES
CC(O)C(O)=O.N
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Synonyms
(±)-Ammonium lactate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Publications (45)
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Journal Impact Factor
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Most Recent
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Bioact Mater
Concerting magnesium implant degradation facilitates local chemotherapy in tumor-associated bone defect. [Abstract]2024 Jun 24:40:445-459. PMID: 39027327 -
Nat Commun
Hyperglycemia exacerbates osteoarthritis by impairing macrophage efferocytosis through modulation of CD11b lactylation. [Abstract]2025 Dec 12. PMID: 41387463 -
J Adv Res
Targeting mesenchymal monocyte-derived macrophages to enhance the sensitivity of glioblastoma to temozolomide by inhibiting TNF/CELSR2/p65/Kla-HDAC1/EPAS1 axis. [Abstract]2025 May 13:S2090-1232(25)00351-0. PMID: 40373963 -
Redox Biol
Histone lactylation drives liver cancer metastasis by facilitating NSF1-mediated ferroptosis resistance after microwave ablation. [Abstract]2025 Apr:81:103553. PMID: 39970777
Ammonium lactate (60%w/w in water) purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Apr:81:103553. [Abstract]
Immunoblot and quantification analyses of NFS1 in HCC cells incubated with 0, 5, or 10 mM lactate after being subjected to either a 47 °C or 37 °C water bath.
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MedComm (2020)
Global Lactylome Reveals Lactylation-Dependent Mechanisms Underlying CXC Motif Chemokine Ligand 12 Expression in Pulmonary Endothelium During Acute Respiratory Distress Syndrome. [Abstract]2025 Aug 29;6(9):e70344. PMID: 40895187 -
Adv Sci (Weinh)
ASH2L-K312-Lac Stimulates Angiogenesis in Tumors to Expedite the Malignant Progression of Hepatocellular Carcinoma. [Abstract]2025 Jul 29:e09477. PMID: 40726441
Ammonium lactate (60%w/w in water) purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul 29:e09477. [Abstract]
Following the direct addition of lactic acid (a final concentration of 100 mM) to the culture medium for 12 h, western blotting, and immunoprecipitation assays revealed a significant increase in the total lactylation and corresponding lysine-312 lactylation levels in ASH2L
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Adv Sci (Weinh)
Histone H3K18 and Ezrin Lactylation Promote Renal Dysfunction in Sepsis-Associated Acute Kidney Injury. [Abstract]2024 May 20:e2307216. PMID: 38767134 -
Cell Death Differ
AARS1-mediated lactylation of H3K18 and STAT1 promotes ferroptosis in diabetic nephropathy. [Abstract]2025 Sep 23. PMID: 40987895 -
Research (Wash D C)
Lactate-Induced Mitochondrial Calcium Uptake 3 Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting Neutrophil Extracellular Trap Formation. [Abstract]2025 May 30:8:0705. PMID: 40452820 -
Cell Death Dis
Lactylation-driven transcriptional activation of FBXO33 promotes gallbladder cancer metastasis by regulating p53 polyubiquitination. [Abstract]2025 Feb 28;16(1):144. PMID: 40021626
Ammonium lactate (60%w/w in water) purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Feb 28;16(1):144. [Abstract]
Lactate (25 mM) significantly increases the mRNA and protein expression of FBXO33.
Ammonium lactate (60%w/w in water) purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Feb 28;16(1):144. [Abstract]
Co-IP detected the effect of lactate on YY1 protein lactylation modification.
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Int J Biol Sci
Macrophage-derived S100A9 promotes diabetic cardiomyopathy by disturbing mitochondrial quality control via STAT3 activation. [Abstract]2025 Apr 22;21(7):3061-3080. PMID: 40384874 -
Clin Cancer Res
Lactate-induced lactylation enhances BMAL1 transcription and nuclear translocation, promoting bevacizumab resistance in glioblastoma through VEGFA. [Abstract]2026 Apr 17. PMID: 41995718 -
J Transl Med
Metabolic interplay between endometrial cancer and tumor-associated macrophages: lactate-induced M2 polarization enhances tumor progression. [Abstract]2025 Aug 18;23(1):923. PMID: 40826409 -
Cell Rep
TRIM65 as a key regulator of ferroptosis and glycolysis in lactate-driven renal tubular injury and diabetic kidney disease. [Abstract]2025 Jul 30;44(8):116091. PMID: 40748757 -
J Ginseng Res
20(S)-ginsenoside Rh2 ameliorates ATRA resistance in APL by modulating lactylation-driven METTL3. [Abstract]2024 May;48(3):298-309. PMID: 38707638
Ammonium lactate (60%w/w in water) purchased from MedChemExpress. Usage Cited in: J Ginseng Res. 2024 May;48(3):298-309. [Abstract]
The expression level of METTL3, YTHDF1, YTHDF2, and YTHDC1 in NB4-R1 and NB4-R2 cells treated with 20 μM oxamate or 20 μM lactate or 1 μM ATRA for 48 h was detected via qRT-PCR.
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J Agric Food Chem
Dietary Lactic Acid Attenuates Ovalbumin-Induced Food Allergy in Mice via Orchestrating Dendritic Cell and T Cell Immune Tolerance. [Abstract]2026 Jun 24;74(24):18768-18778. PMID: 42287222 -
J Agric Food Chem
Lactic Acid Alleviates Cow's Milk Allergy by Regulating Regulatory T Cells and Intestinal Microbiota. [Abstract]2025 Dec 17;73(50):32236-32249. PMID: 41359930 -
Ecotoxicol Environ Saf
MC-LR triggers trophoblast ferroptosis at the maternal-fetal interface by directly targeting PKM2 to reprogram metabolism. [Abstract]2025 Nov 15:307:119451. PMID: 41273830 -
Biochem Pharmacol
CSDE1-mediated histone lactylation modification of the HOXD9 promoter promotes gastric cancer progression. [Abstract]2026 Mar 20:249:117918. PMID: 41864431 -
RSC Adv
Inducible secretion of LIGHT by engineered probiotics enables localized cytokine therapy and robust antitumor immunity. [Abstract]2026 May 18;16(21):19511-19523. PMID: 42157872 -
Cancer Metab
PER2 knockdown drives immunotherapy resistance in gastric cancer via metabolic reprogramming of myeloid-derived suppressor cells. [Abstract]2026 Apr 2;14(1):13. PMID: 41928364 -
Commun Biol
Deoxynivalenol induces ferroptosis via inhibiting glycolysis-H3K18la-STEAP3 axis to promote ovary damage in piglets. [Abstract]2025 Nov 20;8(1):1626. PMID: 41266595 -
Commun Biol
CAF-derived GLUT1 and its role in modulating ovarian cancer progression: a multi-dimensional analysis of the tumor microenvironment. [Abstract]2025 Jul 8;8(1):1020. PMID: 40629043 -
Cancer Immunol Immunother
2024 Oct 3;73(12):254. PMID: 39358478 -
Respir Res
Lactate activates ER stress to promote alveolar epithelial cells apoptosis in pulmonary fibrosis. [Abstract]2024 Nov 9;25(1):401. PMID: 39522031 -
Sci Rep
Integrating single-cell and bulk transcriptomic analyses to explore key lactylation-related genes in benign prostatic hyperplasia. [Abstract]2026 May 25. PMID: 42185567 -
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Cell Signal
PDK4-dependent lactate production and lactylation promote renal calcium oxalate crystal-induced EMT and mitochondrial dysfunction via the TGF-β/SMAD3/GPX4 axis. [Abstract]2026 Jun 27:112701. PMID: 42364861 -
J Cell Mol Med
Identification of LDHA as a Potential Therapeutic Target for Pulmonary Hypertension Through Modulation of Endothelial-To-Mesenchymal Transition. [Abstract]2025 Jul;29(13):e70692. PMID: 40629253 -
J Cell Mol Med
Lactylation-Related Gene LILRB4 Predicts the Prognosis and Immunotherapy of Prostate Cancer Based on Machine Learning. [Abstract]2025 Jun;29(12):e70669. PMID: 40576161 -
Brain Res Bull
LDHA enhances brain injury and apoptosis after intracerebral hemorrhage by promoting P53 transcription through increasing P53 lactylation. [Abstract]2025 May:224:111292. PMID: 40057050 -
FASEB J
Lactate-Driven Epigenetic Reprogramming of Osteogenesis: H3K18 Lactylation Activates m6A/YTHDF1-Dependent YAP1 Signaling to Combat Bone Loss. [Abstract]2026 May 15;40(9):e71765. PMID: 42033168 -
FASEB J
Limonin Is a Novel Hexokinase 2 Inhibitor That Suppresses Hepatic Stellate Cell Activation and Histone Lactylation. [Abstract]2026 Feb 15;40(3):e71547. PMID: 41649270 -
Ren Fail
Lactate induces renal lipid accumulation and aggravates renal fibrosis by inhibiting the PPARα signaling pathway and fatty acid oxidation. [Abstract]2026 Dec;48(1):2630507. PMID: 41808346 -
Vet Res
Neospora caninum hijacks host PFKFB3-driven glycolysis to facilitate intracellular propagation of parasites. [Abstract]2025 Apr 30;56(1):94. PMID: 40307939 -
J Integr Neurosci
2025 Feb 25;24(2):25949. PMID: 40018779 -
Exp Eye Res
Aqueous humor levels of H3K18 lactylation and IL-1β reflect epigenetic-inflammatory activation in lens epithelium and serve as novel potential biomarkers for cataract diagnosis. [Abstract]2026 Jun:267:110981. PMID: 41864487 -
Kaohsiung J Med Sci
Hypoxia-Induced Histone Lactylation Promotes Ferroptosis in Cardiomyocytes via the Wnt/β-Catenin Pathway. [Abstract]2025 Nov 13:e70123. PMID: 41229334 -
Tissue Cell
Gegen Qinlian decoction inhibited M1 macrophage polarization and ulcerative colitis progression through regulating histone lactylation. [Abstract]2024 Jul 9:89:102468. PMID: 39003913 -
J Cardiovasc Transl Res
Hypoxia Aggravates Myocardial Ischemia/Reperfusion Injury Through the Promotion of Ferroptosis via ACSL4 Lactylation. [Abstract]2025 Sep 8. PMID: 40920282 -
Biochem Biophys Res Commun
Hsp60 lactylation promotes mitochondrial dysfunction and trophoblast apoptosis in preeclampsia. [Abstract]2025 Sep 8:778:152379. PMID: 40694902 -
Genes Genomics
Lactate released by lung adenocarcinoma (LUAD) cells promotes M2 macrophage polarization via the GPR132/cAMP/PKA pathway. [Abstract]2025 May;47(5):521-531. PMID: 40053234 -
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Solvent & Solubility
H2O : 116.67 mg/mL (1089.25 mM; Need ultrasonic)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[2]. John Ademola, et al. Clinical evaluation of 40% urea and 12% ammonium lactate in the treatment of xerosis. Am J Clin Dermatol. 2002;3(3):217-22. [Content Brief]
[3]. R M Lavker, et al. Effects of topical ammonium lactate on cutaneous atrophy from a potent topical corticosteroid. J Am Acad Dermatol. 1992 Apr;26(4):535-44. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 9.3362 mL | 46.6810 mL | 93.3620 mL | 233.4049 mL |
| 5 mM | 1.8672 mL | 9.3362 mL | 18.6724 mL | 46.6810 mL | |
| 10 mM | 0.9336 mL | 4.6681 mL | 9.3362 mL | 23.3405 mL | |
| 15 mM | 0.6224 mL | 3.1121 mL | 6.2241 mL | 15.5603 mL | |
| 20 mM | 0.4668 mL | 2.3340 mL | 4.6681 mL | 11.6702 mL | |
| 25 mM | 0.3734 mL | 1.8672 mL | 3.7345 mL | 9.3362 mL | |
| 30 mM | 0.3112 mL | 1.5560 mL | 3.1121 mL | 7.7802 mL | |
| 40 mM | 0.2334 mL | 1.1670 mL | 2.3340 mL | 5.8351 mL | |
| 50 mM | 0.1867 mL | 0.9336 mL | 1.8672 mL | 4.6681 mL | |
| 60 mM | 0.1556 mL | 0.7780 mL | 1.5560 mL | 3.8901 mL | |
| 80 mM | 0.1167 mL | 0.5835 mL | 1.1670 mL | 2.9176 mL | |
| 100 mM | 0.0934 mL | 0.4668 mL | 0.9336 mL | 2.3340 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.