Anti-Mouse CD45.2 Antibody (104.2)
Anti-Mouse CD45.2 Antibody (104.2) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse CD45.2. Anti-Mouse CD45.2 Antibody (104.2) can inhibit B Cell differentiation. Anti-Mouse CD45.2 Antibody (104.2) can be used for the researches of inflammation and immunology, such as LPS (HY-D1056)-induced inflammation and autoimmunity.
For research use only. We do not sell to patients.
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Mouse IgG2a kappa
Mouse
Anti-Mouse CD45.2 Antibody (104.2) (2 mg, i.v., twice at 5 weeks and 1 mg, i.p., twice a week until 24 weeks) alleviates autoimmunity and decreases mortality in BXSB male mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BXSB male mice[2]
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Dosage:2 mg, i.v., at 5 weeks and 1 mg, i.p., until 24 weeks
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Administration:Twice a week
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Result:Decreased mortality.
Showed mild proteinuria.
Reduced the severity of membranoproliferative glomerulonephritis.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
Flow cytometry; in vivo CD45.2 blockade; in vitro CD45.2 blockade; Immunohistochemistry (frozen)
Chemical Information
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Molecular Weight 150 kDa
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SMILES
[Anti-Mouse CD45.2 Antibody (104.2)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Russo AJ, et al. Intracellular immune sensing promotes inflammation via gasdermin D-driven release of a lectin alarmin. Nat Immunol. 2021 Feb;22(2):154-165. [Content Brief]
[2]. Yakura H, et al. Alleviation of autoimmunity in BXSB mice by monoclonal alloantibody to Ly-5 (CD45). Eur J Immunol. 1989 Aug;19(8):1505-8. [Content Brief]
[3]. Yakura H, et al. On the function of Ly-5 in the regulation of antigen-driven B cell differentiation. Comparison and contrast with Lyb-2. J Exp Med. 1983 Apr 1;157(4):1077-88. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse CD45.2 Antibody (104.2) Related Classifications
HY-P990268 Related Classifications
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