Anti-Mouse CD73 Antibody (TY/23) 

Anti-Mouse CD73 Antibody (TY/23) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD73. Anti-Mouse CD73 Antibody (TY/23) can neutralize CD73. Anti-Mouse CD73 Antibody (TY/23) can be used for the researches of cancer, infection and immunology, such as B16F10 tumor and murine cytomegalovirus infection^[1][2].

Rat IgG2a kappa

Rat IgG2a kappa, Isotype Control

Mouse

CD73

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD73 Antibody (TY/23) (100 μg, i.p., at days 3, 7, 10, 14, 17, 21, and 24) suppresses MC38-ova tumor growth in transgenic DEREG mice models^[1].
Anti-Mouse CD73 Antibody (TY/23) (200 μg, i.v., 1 day prior and 2 h prior tumor inoculation) suppresses the development of B16F10 lung metastases in wild-type mice^[1].
Anti-Mouse CD73 Antibody (TY/23) (200 μg, i.v., every other day for 2 weeks) improves OT-I T cells function from the kidney and spleen in murine cytomegalovirus-infected mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

23959  [NCBI]

Q61503

in vivo CD73 blockade; in vitro CD73 blockade

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Mouse CD73 Antibody (TY/23)]

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Stagg J, et al. CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis. Cancer Res. 2011 Apr 15;71(8):2892-900.  [Content Brief]

  [2]. Smith CJ, et al. Inhibitory Molecules PD-1, CD73 and CD39 Are Expressed by CD8+ T Cells in a Tissue-Dependent Manner and Can Inhibit T Cell Responses to Stimulation. Front Immunol. 2021 Jul 15;12:704862.  [Content Brief]