Anti-Mouse TIM-1/CD365 Antibody (3D10)
Anti-Mouse TIM-1/CD365 Antibody (3D10) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse TIM-1/CD365. Anti-Mouse TIM-1/CD365 Antibody (3D10) can block mouse T cell immunoglobulin and mucin domain 1 (TIM-1) also known as CD365. Anti-Mouse TIM-1/CD365 Antibody (3D10) can be used for the researches of inflammation, immunology and cardiovascular disease, such as graft-versus-host disease (GVHD), airway inflammation and atherosclerosis.
For research use only. We do not sell to patients.
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Rat IgG1 kappa
Mouse
TIM-1/CD365
Anti-Mouse TIM-1/CD365 Antibody (3D10) (24 h before ozone exposure) prevents the development of ozone-induced airway hyperreactivity and airway inflammation in wildtype mice[2].
Anti-Mouse TIM-1/CD365 Antibody (3D10) (400 μg, i.p., at days -1, 3, 7, 11, and 17) prevents graft-versus-host disease (GVHD) in lethally irradiated BALB/c (H-2d) mice received allogeneic B6 BM and Tcon cells (H-2b)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:High fat diet ldlr−/− mice[1]
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Dosage:200 μg
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Administration:Intraperitoneally injection, twice a week for 4 weeks, companied anti-Tim-4 antibody
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Result:Increased TUNEL+ cells in lesions.
Impaired efferocytosis.
Enhanced CD4+ T cell numbers within the lesions.
Increased Th2 cytokines in the supernatants of anti-CD3/CD28-stimulated splenocytes.
Induced IgG1 antibodies against oxLDL and MDA-LDL.
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Animal Model:Lethally irradiated BALB/c (H-2d) mice received allogeneic B6 BM and Tcon cells (H-2b)[3]
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Dosage:400 μg
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Administration:Intraperitoneally injection, at days -1, 3, 7, 11, and 17
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Result:Had less GVHD.
Reduced GVHD score and severity.
Reduced inflammatory factors and infiltrating cells.
Q5QNS5-1
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
in vivo TIM-1 blockade; in vitro TIM-1 blockade
Chemical Information
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Molecular Weight 150 kDa
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SMILES
[Anti-Mouse TIM-1/CD365 Antibody (3D10)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Foks AC, et al. Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice. Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):456-65. [Content Brief]
[2]. Kim HY, et al. T-cell immunoglobulin and mucin domain 1 deficiency eliminates airway hyperreactivity triggered by the recognition of airway cell death. J Allergy Clin Immunol. 2013 Aug;132(2):414-25.e6. [Content Brief]
[3]. Iliopoulou BP, et al. Blockade of TIM-1 on the donor graft ameliorates graft-versus-host disease following hematopoietic cell transplantation. Blood Adv. 2019 Nov 12;3(21):3419-3431. [Content Brief]
[4]. Ikeda M, et al. Pr1E11, a novel anti-TROP-2 antibody isolated by adenovirus-based antibody screening, recognizes a unique epitope. Biochem Biophys Res Commun. 2015 Mar 20;458(4):877-82. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse TIM-1/CD365 Antibody (3D10) Related Classifications
HY-P990822 Related Classifications
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