Anti-Rat CD8α Antibody (OX-8)
Based on 1 Customer Validation
Anti-Rat CD8α Antibody (OX-8) is an anti-rat CD8α IgG1 monoclonal antibody. Anti-Rat CD8α Antibody (OX-8) can deplete CD8+ T cells. Anti-Rat CD8α Antibody (OX-8) can enhance airway remodeling. Anti-Rat CD8α Antibody (OX-8) can be used for researches on allergic conditions and infections such as RHV-rn1 virus infection and asthma.
For research use only. We do not sell to patients.
- Purity : 96.90%
- Molecular Weight:150 kDa
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
Isotype
Mouse IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Rat
IC50 & Target
CD8α
In Vivo
Anti-Rat CD8α Antibody (OX-8) (250 μg, i.p., on day 13, 19 and 25) significantly enhances airway remodeling in male Brown Norway rats with an Ovalbumin (OVA) (HY-W250978) induced asthma model[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Lewis rats (7-8 weeks) with a RHV-rn1 virus infection model[1]
-
Dosage:0.5 mg for first-dose, 0.2 mg for subsequent doses
-
Administration:Intravenous injection (i.v.), on day -2, 5 and 12
-
Result:Significantly prolonged the duration of viral infection.
Decreased the number of CD8+ T cells.
-
Animal Model:OVA (1 mg) induced male Brown Norway rats (6-7 weeks)[2]
-
Dosage:250 μg
-
Administration:Intraperitoneal injection (i.p.), on day 13, 19 and 25
-
Result:Increased PCNA positive cells.
Increased PAS positive cells.
Increased the positive area of α-SMA.
Gene ID
Accession
P01731-1
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
-
Product Image
Application
in vivo CD8+ T cell depletion; Flow cytometry; Immunohistochemistry (paraffin); Immunohistochemis
Chemical Information
-
Appearance Liquid
-
Molecular Weight 150 kDa
-
Color Colorless to light yellow
-
SMILES
[Anti-Rat CD8α Antibody (OX-8)]
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
-
Data Sheet (261 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
References
[1]. Hartlage AS, et al. Vaccination to prevent T cell subversion can protect against persistent hepacivirus infection. Nat Commun. 2019 Mar 7;10(1):1113. [Content Brief]
[2]. Tsuchiya K, et al. Depletion of CD8+ T cells enhances airway remodelling in a rodent model of asthma. Immunology. 2009 Jan;126(1):45-54. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Rat CD8α Antibody (OX-8) Related Classifications
HY-P990126 Related Classifications
Powered by Bioz