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ACD Antibody (YA8057)(PBS only)

(Synonyms: PIP1; PTOP; TINT1; TPP1)

ACD Antibody (YA8057) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ACD.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    ICC/IF, FC

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • ACD Antibody (YA8057)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
Dilution Ratio 1:100-250 1:100

Product Details

Description

ACD Antibody (YA8057) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ACD.

  • Host Mouse
  • Species Reactivity
    Human
  • Calculated Molecular Weight Predicted band size: 57.6 kDa
Immunogen

Full length human recombinant protein of human ACD produced in HEK293T cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    ACD component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis

  • Subcellular Localization

    Nucleus,Chromosome, telomere

  • Isoforms & Post-Translational Modification

    Q96AP0 has two isomers: Q96AP0-3: 48967 Da (predicted); Q96AP0-2: 48627 Da (predicted).

  • Subunit

    Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1

  • SwissProt ID

    Q96AP0

  • Synonyms

    PIP1; PTOP; TINT1; TPP1

ACD Antibody (YA8057)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • ACD Antibody (YA8057)(PBS only) Product Image
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  • ACD Antibody (YA8057)(PBS only) Product Image