ARFGAP1 Antibody (YA4372)
(Synonyms: ARF1GAP; HRIHFB2281)ARFGAP1 Antibody (YA4372) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to ARFGAP1.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
WB, FC, ELISA
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:400 | 1:10000 |
Product Details
ARFGAP1 Antibody (YA4372) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to ARFGAP1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 45 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 45 kDa
Purified recombinant fragment of human ARFGAP1 (AA: 270-414) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ARFGAP1 is a GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine
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Subcellular Localization
Cytoplasm; Golgi apparatus
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Isoforms & Post-Translational Modification
Q8N6T3 has 5 isomers: Q8N6T3-1: 44668 Da (predicted); Q8N6T3-2: 45676 Da (predicted); Q8N6T3-3: 44467 Da (predicted); Q8N6T3-4: 31476 Da (predicted); Q8N6T3-5: 39705 Da (predicted).
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Subunit
Interacts with ARF1. Interacts with the COPI coat proteins, KDELR1 and TMED2. The interaction with TMED2 inhibits the GAP activity (By similarity)
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SwissProt ID
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Synonyms
ARF1GAP; HRIHFB2281
Documentation
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