ARFGAP1 - ADP ribosylation factor GTPase activating protein 1 Gene

Also Known as ARF1GAP; HRIHFB2281

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55738

About ARFGAP1

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,272,813-63,289,790 (from NCBI)

This gene has 23 transcripts (splice variants), 198 orthologues and 28 paralogues. Ubiquitous expression in spleen (RPKM 11.8), testis (RPKM 11.1) and 25 other tissues.

Summary

The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

ARFGAP1 Products (5)

mRNA Protein Name
NM_001281482.2 NP_001268411.1 ADP-ribosylation factor GTPase-activating protein 1 isoform c
NM_001281483.2 NP_001268412.1 ADP-ribosylation factor GTPase-activating protein 1 isoform d
NM_001281484.2 NP_001268413.1 ADP-ribosylation factor GTPase-activating protein 1 isoform e
NM_018209.4 NP_060679.1 ADP-ribosylation factor GTPase-activating protein 1 isoform a
NM_175609.3 NP_783202.1 ADP-ribosylation factor GTPase-activating protein 1 isoform b

ARFGAP1 Protein Structure

ArfGap

ArfGap: Putative GTPase activating protein for Arf (8 - 115)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
Protein Preferred Names Protein Names

ADP-ribosylation factor GTPase-activating protein 1

  • ARF1-directed GTPase-activating protein

ARFGAP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARFGAP1 Q8N6T3 FOS Homo sapiens Q6FG41
Y2H Prey Pooling
25416956
Intra
ARFGAP1 Q8N6T3 GABARAPL2 Homo sapiens P60520
Validated Y2H
25416956
Intra
ARFGAP1 Q8N6T3 TRIM23 Homo sapiens P36406
Validated Y2H
25416956
Intra
ARFGAP1 Q8N6T3 GRN Homo sapiens P28799
Y2H Prey Pooling
25416956
Intra
ARFGAP1 Q8N6T3 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

ARFGAP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84675 ARFGAP1 Antibody (YA4372) WB, FC, ELISA Human, Mouse
HY-P84675A ARFGAP1 Antibody (YA4372)(PBS only) WB, FC, ELISA Human, Mouse

Related Diseases

Diseases Alias
Ceroid Lipofuscinosis, Neuronal, 4

  • Ceroid Lipofuscinosis, Neuronal, Parry Type

  • Cln4b Disease

  • Neuronal Ceroid Lipofuscinosis 4b

  • CLN4B

  • Autosomal Dominant Neuronal Ceroid Lipofuscinosis 4b

  • Ceroid Lipofuscinosis, Neuronal, 4b, Autosomal Dominant

  • Adult Neuronal Ceroid Lipofuscinosis

  • CLN4

  • Ceroid Lipofuscinosis, Neuronal, 4 , Autosomal Dominant

  • Neuronal Ceroid Lipofuscinosis 4

  • Neuronal Ceroid Lipofuscinosis 4 Parry Type

  • Adult Neuronal Ceroid Lipofuscinosis 4b

  • Kuf'S Disease Type B

  • Kuf'S Disease, Autosomal Dominant

  • Cln4 Disease

  • Parry Disease

  • Ceroid Lipofuscinosis, Neuronal 4

  • Ceroid Lipofuscinosis, Neuronal, 4b , Autosomal Dominant

  • Kufs Disease Autosomal Dominant

  • Neuronal Ceroid Lipofuscinosis Parry Type

  • Ceroid Lipofuscinosis, Neuronal, 4, Parry Type

  • Lipofuscinosis, Ceroid, Neuronal, Type 4, Parry Type
Hypotrichosis-Lymphedema-Telangiectasia Syndrome

  • HLTS

  • Hypotrichosis Lymphedema Telangiectasia Syndrome

  • Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome

  • Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome
Hypersensitivity Reaction Type Iv Disease

  • Immunoproliferative Disorders

  • Immunoproliferative Disease
Autoimmune Lymphoproliferative Syndrome

  • ALPS

  • Canale-Smith Syndrome

  • Autoimmune Lymphoproliferative Syndrome, Type Ia

  • Autoimmune Lymphoproliferative Syndrome, Type Ib

  • Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant

  • Css

  • Autoimmune Lymphoproliferative Syndrome, Type 1b

  • Autoimmune Lymphoproliferative Syndrome, Type 1a

  • Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant

  • Fas Deficiency

  • Autoimmune Lymphoproliferative Syndrome 1a

  • ALPS1A

  • Autoimmune Lymphoproliferative Syndrome Type Ia

  • Autoimmune Lymphoproliferative Syndrome 1b

  • ALPS1B

  • Autoimmune Lymphoproliferative Syndrome Type Ib
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12762 QS11 99.10% Unkown
HY-RS00899 ARFGAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00901 ARFGAP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21984 Arfgap3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ARFGAP1 VGNC VGNC:69835
Bos taurus ARFGAP1 VGNC VGNC:56176
Felis catus ARFGAP1 VGNC VGNC:59866
Mus musculus ARFGAP1 MGD MGI:2183559
Canis familiaris ARFGAP1 VGNC VGNC:38032
Rattus norvegicus ARFGAP1 RGD RGD:708452
Others ARFGAP1 NCBI