ASCC2 Antibody (YA7978)
(Synonyms: ASC1p100; p100)ASCC2 Antibody (YA7978) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ASCC2.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:100-250 | 1:100 |
Product Details
ASCC2 Antibody (YA7978) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ASCC2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 86.2 kDa
Full length human recombinant protein of human ASCC2 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ASCC2 is an Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes. Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes[1][2][3][4][5].
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Subcellular Localization
Nucleus,Nucleus speckle
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Expression
Tissue_Specificity: Ubiquitous -
Isoforms & Post-Translational Modification
Q9H1I8 has three isomers: Q9H1I8-1: 86360 Da (predicted); Q9H1I8-2: 41794 Da (predicted); Q9H1I8-3: 77369 Da (predicted).
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Subunit
Identified in the ASCC complex that contains ASCC1, ASCC2 and ASCC3 (PubMed:29144457, PubMed:29997253)
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SwissProt ID
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Synonyms
ASC1p100; p100
Documentation
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