ATL3 Antibody (YA6469)
(Synonyms: 4633402C03Rik antibody; 5730596K20Rik antibody; AI465397 antibody; ATL3 antibody; ATLA3_HUMAN antibody; Atlastin 3 like antibody; Atlastin GTPase 3 antibody; Atlastin-3 antibody; AW228836 antibody; DKFZp564J0863 antibody; 4633402C03Rik antibody; 5730596K20Rik antibody; AI465397 antibody; ATL3 antibody; ATLA3_HUMAN antibody; Atlastin 3 like antibody; Atlastin GTPase 3 antibody; Atlastin-3 antibody; AW228836 antibody; DKFZp564J0863 antibody; MGC28761 antibody; )ATL3 Antibody (YA6469) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATL3.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF, IHC-P, FC
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Reactivity :
Human, Mouse, Rat, Monkey
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:1000 | 1:100 | 1:1000 | 1:1000 |
Product Details
ATL3 Antibody (YA6469) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATL3.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat, Monkey
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Observed Molecular WeightObserved band size: 61 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 61 kDa
Recombinant protein within human ATL3 aa 1-488 / 541.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ATL3 is an Atlastin-3 (ATL3) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect. Two atlastin-3 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle[1][2][3][4][5].
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Subcellular Localization
Endoplasmic reticulum membrane
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Expression
Tissue_Specificity: Expressed in the central nervous system and in dorsal root ganglia neurons. Expressed in peripheral tissues (at protein level) -
Isoforms & Post-Translational Modification
Q6DD88: 541 amino acids, molecular weight 60542 Da.
Phosphorylation at Ser-193 by NEK1 promotes the closed conformational state preventing excessive mitochondrial membrane permeability and subsequent apoptotic cell death after injury (PubMed:20230784)丨Ubiquitinated (PubMed:25621951, PubMed:32047033) -
Subunit
Monomeric and homodimeric
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SwissProt ID
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Synonyms
4633402C03Rik antibody; 5730596K20Rik antibody; AI465397 antibody; ATL3 antibody; ATLA3_HUMAN antibody; Atlastin 3 like antibody; Atlastin GTPase 3 antibody; Atlastin-3 antibody; AW228836 antibody; DKFZp564J0863 antibody; 4633402C03Rik antibody; 5730596K20Rik antibody; AI465397 antibody; ATL3 antibody; ATLA3_HUMAN antibody; Atlastin 3 like antibody; Atlastin GTPase 3 antibody; Atlastin-3 antibody; AW228836 antibody; DKFZp564J0863 antibody; MGC28761 antibody;
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