C1R Antibody (YA7929)
(Synonyms: complement component 1; r subcomponent)C1R Antibody (YA7929) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C1R.
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Host:
Mouse
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Isotype:
IgG1
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Application:
FC
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
FC
FC: Flow Cytometry
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|---|---|
| Dilution Ratio | 1:100 |
Product Details
C1R Antibody (YA7929) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C1R.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 80 kDa
Human recombinant protein fragment corresponding to amino acids 262-562 of human C1R produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
C1R serine protease component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C1R catalyzes the first enzymatic step in the classical complement pathway: it is activated by the C1Q subcomplex of the C1 complex, which associates with IgG or IgM immunoglobulins complexed with antigens to form antigen-antibody complexes on the surface of pathogens. Immunoglobulin-binding promotes the autocatalytic cleavage and activation of C1R. Activated C1R then cleaves and activates C1S, the second protease of the classical complement pathway. It is unclear if C1R activates C1S within single, strained C1 complexes or between neighboring C1 complexes on surfaces[1][2][3][4][5][6][7][8][9][10][11].
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Subcellular Localization
Secreted,Cell surface
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Isoforms & Post-Translational Modification
P00736: 705 amino acids, molecular weight 80119 Da.
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Subunit
Core component of the complement C1 complex, a calcium-dependent complex composed of 1 molecule of the C1Q subcomplex, 2 molecules of C1R and 2 molecules of C1S (PubMed:19473974, PubMed:28104818, PubMed:29311313, PubMed:2988513, PubMed:2989825, PubMed:34155115, PubMed:6952210)
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SwissProt ID
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Synonyms
complement component 1; r subcomponent
Documentation
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