C2orf43 Antibody (YA8230)
(Synonyms: C2orf43; hLDAH)C2orf43 Antibody (YA8230) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C2orf43.
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Host:
Mouse
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Isotype:
IgG1
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Application:
FC
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
FC
FC: Flow Cytometry
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|---|---|
| Dilution Ratio | 1:100 |
Product Details
C2orf43 Antibody (YA8230) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C2orf43.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 37.1 kDa
Full length human recombinant protein of human C2orf43 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
C2orf43 is a Probable serine lipid hydrolase associated with lipid droplets. Has low cholesterol esterase activity. Appears to lack triglyceride lipase activity. Involved in cholesterol and triglyceride homeostasis; has opposing effects, stimulating cellular triglyceride accumulation and cellular cholesterol release. Acts antagonistically with PNPLA2/ATGL in regulation of cellular lipid stores. May regulate triglyceride accumulation indirectly through stimulation of PNPLA2/ATGL ubiquitination and proteasomal degradation. Promotes microtubule-dependent lipid droplet fusion. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages[1][2].
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Subcellular Localization
Lipid droplet,Endoplasmic reticulum
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Expression
Tissue_Specificity: Present in macrophage-rich areas in atherosclerotic lesions (at protein level) (PubMed:24357060). Expressed in monocytes and monocyte-derived macrophages (at protein level) (PubMed:24357060) -
Isoforms & Post-Translational Modification
Q9H6V9 has four isomers: Q9H6V9-1: 37319 Da (predicted); Q9H6V9-2: 37989 Da (predicted); Q9H6V9-3: 32029 Da (predicted); Q9H6V9-4: 22663 Da (predicted).
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SwissProt ID
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Synonyms
C2orf43; hLDAH
Documentation
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