C2orf43 Antibody (YA8230)

Cat. No.: HY-P88546: Data Sheet User Guide for Antibodies
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C2orf43 Antibody (YA8230) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C2orf43.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

C2orf43 Antibody (YA8230) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C2orf43.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 37.1 kDa

Species Reactivity

Human

SwissProt ID

Q9H6V9

Immunogen

Full length human recombinant protein of human C2orf43 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
FC FC: Flow Cytometry	1:100

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Probable serine lipid hydrolase associated with lipid droplets (By similarity). Has low cholesterol esterase activity (By similarity). Appears to lack triglyceride lipase activity (By similarity). Involved in cholesterol and triglyceride homeostasis; has opposing effects, stimulating cellular triglyceride accumulation and cellular cholesterol release (PubMed:24357060, PubMed:28578400). Acts antagonistically with PNPLA2/ATGL in regulation of cellular lipid stores (PubMed:28578400). May regulate triglyceride accumulation indirectly through stimulation of PNPLA2/ATGL ubiquitination and proteasomal degradation (PubMed:28578400). Promotes microtubule-dependent lipid droplet fusion (PubMed:28578400). Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages (By similarity)

Subcellular Localization：Lipid droplet,Endoplasmic reticulum

Expression：
Tissue_Specificity: Present in macrophage-rich areas in atherosclerotic lesions (at protein level) (PubMed:24357060). Expressed in monocytes and monocyte-derived macrophages (at protein level) (PubMed:24357060)

Isoforms & Post-Translational Modification：Q9H6V9 has four isomers: Q9H6V9-1: 37319 Da (predicted); Q9H6V9-2: 37989 Da (predicted); Q9H6V9-3: 32029 Da (predicted); Q9H6V9-4: 22663 Da (predicted).

Synonyms

C2orf43; hLDAH

Documentation

User Guide for Antibodies (1077 KB)