C7 Antibody (YA7067)
(Synonyms: C7 antibody; CO7_HUMAN antibody; complement component 7 antibody; Complement component C7 antibody)C7 Antibody (YA7067) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C7.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, ICC/IF, FC
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Reactivity :
Human
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Formulation:
Supplied in 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:50-1:200 | FC: 1:50-1:100 |
Product Details
C7 Antibody (YA7067) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C7.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman Predicted Reactivity: Mouse,Rat
Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
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Observed Molecular WeightObserved band size: 94 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 94 kDa
Recombinant protein within Human C7 aa 498-641 / 843.
Endogenous
Protein A affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
C7 component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C7 serves as a membrane anchor. During MAC assembly, associates with C5b and C6 to form the C5b-7 complex, a key lipophilic precursor of the MAC complex, which associates with the outer leaflet and reduces the energy for membrane bending[1][2][3][4][5][6].
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Subcellular Localization
Secreted,Target cell membrane
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Isoforms & Post-Translational Modification
P10643: 843 amino acids, molecular weight 93518 Da.
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Subunit
Monomer or dimer; as a C5b-7 complex it can also form multimeric rosettes (PubMed:22832194, PubMed:30552328)
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SwissProt ID
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Synonyms
C7 antibody; CO7_HUMAN antibody; complement component 7 antibody; Complement component C7 antibody
Documentation
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