Calsequestrin 1 Antibody (YA1561)
(Synonyms: Calmitin; Calmitine; Calsequestrin; Calsequestrin-1; CASQ; Casq1; PDIB1)
Based on 1 Customer Validation
Calsequestrin 1 Antibody (YA1561) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Calsequestrin 1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:1000-1:2000 | 1:100-1:200 | 1:50-1:100 |
Product Details
Calsequestrin 1 Antibody (YA1561) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Calsequestrin 1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 63 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 45 kDa
Entrez Gene: 844 Human ; 12372 Mouse ; 686019 Rat
SwissProt: P31415 Human ; O09165 Mouse ; P19633 Rat
OMIM: 616231 Human
A synthesized peptide derived from human Calsequestrin 1 aa100-150/396.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Calsequestrin 1 is a Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity[1][2].
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Subcellular Localization
Endoplasmic reticulum; Sarcoplasmic reticulum; Sarcoplasmic reticulum lumen; Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side; Mitochondrion matrix
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Expression
Tissue_specificity:Expressed in myoblasts (at protein level) -
Subunit
Monomer; increases in response to a depletion of intracellular calcium (PubMed:26136523, PubMed:27185316). Homodimer (PubMed:26136523, PubMed:27185316, PubMed:28895244).
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SwissProt ID
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Synonyms
Calmitin; Calmitine; Calsequestrin; Calsequestrin-1; CASQ; Casq1; PDIB1
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Research Field
Signal Transduction
Documentation
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