CAMLG Antibody (YA8474)
(Synonyms: CAML)CAMLG Antibody (YA8474) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CAMLG.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 | 1:100 |
Product Details
CAMLG Antibody (YA8474) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CAMLG.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 32.8 kDa
Full length human recombinant protein of human CAMLG produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CAMLG is required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells[1][2][3][4][5].
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Subcellular Localization
Endoplasmic reticulum membrane
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Expression
Tissue_Specificity: Ubiquitous. Highest levels in brain, testis and ovary -
Isoforms & Post-Translational Modification
P49069: 296 amino acids, molecular weight 32953 Da.
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Subunit
Component of the Golgi to ER traffic (GET) complex, which is composed of GET1/WRB, CAMLG/GET2 and GET3/TRC40 (PubMed:23041287, PubMed:24392163, PubMed:32910895)
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SwissProt ID
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Synonyms
CAML
Documentation
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