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CD127 Antibody (YA3831)(PBS only)

(Synonyms: IL7R; ILRA; IL7RA; CDW127; IL-7R-alpha)

CD127 Antibody (YA3831) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD127.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG

  • Application:

    WB, FC, ELISA

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • CD127 Antibody (YA3831)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
FC Info
FC: Flow Cytometry
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:500-1:2000 1:200-1:400 1:10000

Product Details

Description

CD127 Antibody (YA3831) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD127.

  • Host Mouse
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 70 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 52 kDa
Immunogen

Purified recombinant fragment of human CD127 (AA: extra 21-239) expressed in E. Coli.

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    CD127 (IL-7Rα, IL7R) is the IL-7 receptor α-chain and a key immune molecule for maintaining T-cell survival, development, and memory formation. It is highly expressed on naive and memory T cells but expressed at low levels on regulatory T cells (Tregs); therefore, it is widely used in T-cell subset identification, immune monitoring, and research into tumor immunology, infection immunology, and autoimmune diseases.

  • Subcellular Localization

    Cell membrane; Single-pass type I membrane protein; Cell membrane; Single-pass type I membrane protein; Secreted

  • Isoforms & Post-Translational Modification

    CD127 has 4 isomers: P16871-1: 51579 Da (predicted); P16871-2: 34018 Da (predicted); P16871-3: 29936 Da (predicted); P16871-4: 28722 Da (predicted).
    N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form;Ubiquitinated by MARCHF8; leading to lysosomal degradation

  • Subunit

    The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R. Interacts with CD53

  • SwissProt ID

    P16871

  • Gene ID
    3575 [NCBI]
  • Synonyms

    IL7R; ILRA; IL7RA; CDW127; IL-7R-alpha

CD127 Antibody (YA3831)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • CD127 Antibody (YA3831)(PBS only) Product Image