CD15 Antibody (YA4774)
(Synonyms: FUT4; ELFT; FCT3A; Alpha-; 1; 3; -fucosyltransferase; ELAM-1 ligand fucosyltransferase; Fucosyltransferase 4; Fucosyltransferase IV; Fuc-TIV; FucT-IV; Galactoside 3-L-fucosyltransferase)CD15 Antibody (YA4774) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD15.
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Host:
Mouse
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Application:
IHC-P, ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:1000 | 1:10000 |
Product Details
CD15 Antibody (YA4774) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD15.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
Synthesized peptide of human CD15.
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD15 is a carbohydrate antigen formed by glycosyltransferase catalysis and exists on glycoproteins and glycolipids on the cell surface. CD15 is mainly expressed on neutrophils, eosinophils, and some myeloid cells. Through interaction with selectins such as E-selectin and P-selectin, it mediates leukocyte rolling, adhesion, and migration, playing an important role in acute inflammation and immune defense.
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Subcellular Localization
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein
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Expression
Tissue_specificity:It is expressed at low levels in bone marrow mesenchymal stem cells; it is also expressed in immature promyelocytes in umbilical cord blood and in peripheral blood myeloid and lymphoid cell populations. -
Isoforms & Post-Translational Modification
CD15 has 2 isomers: P22083-1: 59084 Da (predicted); P22083-2: 45629 Da (predicted).
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SwissProt ID
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Synonyms
FUT4; ELFT; FCT3A; Alpha-; 1; 3; -fucosyltransferase; ELAM-1 ligand fucosyltransferase; Fucosyltransferase 4; Fucosyltransferase IV; Fuc-TIV; FucT-IV; Galactoside 3-L-fucosyltransferase
Documentation
[1]. Goelz SE, et al. ELFT: a gene that directs the expression of an ELAM-1 ligand. Cell. 1990 Dec 21;63(6):1349-56. [Content Brief]
[2]. Lowe JB, et al. Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion. J Biol Chem. 1991 Sep 15;266(26):17467-77. [Content Brief]
[3]. Mondal N, et al. Distinct human α(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells. J Biol Chem. 2018 May 11;293(19):7300-7314. [Content Brief]
[4]. Nakayama F, et al. CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV. J Biol Chem. 2001 May 11;276(19):16100-6. [Content Brief]
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