FUT4 - fucosyltransferase 4 Gene

Also Known as LeX; CD15; ELFT; FCT3A; FUTIV; SSEA-1; FUC-TIV

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2526

About FUT4

Cytogenetic location: 11q21 Genomic coordinates (GRCh38): 11:94,543,921-94,549,895 (from NCBI)

This gene has 1 transcript (splice variant), 272 orthologues and 7 paralogues.

Summary

The product of this gene transfers fucose to N-acetyllactosamine Polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009]

FUT4 Products (1)

mRNA Protein Name
NM_002033.4 NP_002024.1 alpha-(1,3)-fucosyltransferase 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity IDA
IDA: Inferred from direct assay
1740457 GOA
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity IMP
IMP: Inferred from mutant phenotype
23192350 GOA
Biological Process GO Annotation Evidence References Source
involved in Lewis x epitope biosynthetic process IDA
IDA: Inferred from direct assay
29593094 GOA
involved in glycosphingolipid biosynthetic process IDA
IDA: Inferred from direct assay
29593094 GOA
involved in oligosaccharide metabolic process IDA
IDA: Inferred from direct assay
1740457 GOA
involved in protein N-linked glycosylation IDA
IDA: Inferred from direct assay
29593094 GOA
involved in protein O-linked glycosylation IDA
IDA: Inferred from direct assay
29593094 GOA
involved in regulation of leukocyte cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
23192350 GOA
Cellular Component GO Annotation Evidence References Source
located in trans-Golgi network IDA
IDA: Inferred from direct assay
23192350 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FUT4 Protein Structure

Glyco_transf_10

Glyco_transf_10: Glycosyltransferase family 10 (fucosyltransferase) C-term (155 - 529)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 530 a.a.
Protein Preferred Names Protein Names

alpha-(1,3)-fucosyltransferase 4

  • 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase

FUT4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81582 CD15 Antibody (YA1327) IHC-P Human
HY-P85082 CD15 Antibody (YA4774) IHC-P, ICC/IF, ELISA Human
HY-P85674 CD15 Antibody (YA5366) IHC-P, ICC/IF Human

Related Diseases

Diseases Alias
Hodgkin'S Lymphoma, Mixed Cellularity

  • Hodgkin'S Disease, Mixed Cellularity

  • Hodgkins Lymphoma, Mixed Cellularity

  • Mixed Cellularity Hodgkin Lymphoma
Hodgkin'S Lymphoma, Lymphocytic-Histiocytic Predominance

  • Hodgkin Disease

  • Hodgkin Lymphoma, Lymphocyte-Rich

  • Hodgkin Lymphoma, Lymphocytic-Histiocytic Predominance

  • Hodgkin'S Disease, Lymphocyte Predominance

  • Lymphocyte Rich Hodgkin'S Disease

  • Lymphocyte Rich Classical Hodgkin Lymphoma
Gray Zone Lymphoma

  • B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma
Mediastinal Gray Zone Lymphoma

  • Mediastinal B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma
Mediastinal Malignant Lymphoma

  • Lymphoma Of Mediastinum

  • Mediastinal Lymphoma
Sickle Cell Anemia

  • Hemoglobin Sc Disease

  • Anemia, Sickle Cell

  • Hbsc Disease

  • Sickle Cell-Hemoglobin C Disease Syndrome

  • Hb Ss Disease

  • Sickle Cell Trait

  • Drepanocytosis

  • Haemoglobin Sc Disease

  • Hb Sc Disease

  • Hb-S/Hb-C Disease

  • Hb-Ss Disease Without Crisis

  • Hemoglobin S Disease Without Crisis

  • Sickle Cell Anaemia

  • Sickle-Cell/Hb-C Disease Without Crisis

  • Sickle Cell - Hemoglobin C Disease

  • Hbs Disease

  • Hemoglobin S Disease

  • Sickling Disorder Due To Hemoglobin S

  • SKCA

  • Sickle Cell Disease

  • Sickle Cell-Hemoglobin C Disease

  • Sickle-Cell Disease Carrier

  • Sickle-Cell Heterozygous Disorder

  • Haemoglobin A-S Genotype

  • Hb-S - [Sickle Cell Haemoglobin] Carrier

  • Sickle Cell Haemoglobin Trait

  • As - [Sickle Cell Trait]

  • Hbas - [Sickle Cell Haemoglobin Trait]

  • Sickle-Cell Trait Haemoglobin Disease

  • Haemoglobin Sickle Cell Trait Disorder

  • Heterozygous Sickle Cell Trait

  • Hbas - [Heterozygous Haemoglobin S]
Helicobacter Pylori Infection

  • Helicobacter Pylori Infection, Susceptibility To

  • H. Pylori Infection, Susceptibility To

  • H. Pylori Infection

  • Helicobacter Pylori Infections
Hodgkin'S Lymphoma, Lymphocytic Depletion

  • Hodgkin Lymphoma, Lymphocyte Depletion

  • Hodgkin'S Disease, Lymphocytic Depletion

  • Hodgkin'S Lymphocytic Depletion Of Unspecified Site

  • Lymphocyte-Depleted Classical Hodgkin Lymphoma

  • Classic Hodgkin Lymphoma, Lymphocyte-Depleted Type

  • Hodgkin Disease, Lymphocytic Depletion

  • Hodgkin Lymphocytic Depletion
Colon Adenocarcinoma

  • Adenocarcinoma Of Colon

  • Adenocarcinoma Of The Colon

  • Colonic Adenocarcinoma
Hodgkin'S Lymphoma, Nodular Sclerosis

  • Classical Hodgkin Lymphoma, Nodular Sclerosis

  • Classic Hodgkin Lymphoma, Nodular Sclerosis Type

  • Nodular Sclerosis Hodgkin Lymphoma

  • Hodgkin'S Disease, Nodular Sclerosis

  • Hodgkin Disease, Nodular Sclerosis

  • Hodgkin Lymphoma, Nodular Sclerosis

  • Hodgkin Nodular Sclerosis
Childhood Infratentorial Neoplasm

  • Pediatric Infratentorial Tumor
Epididymis Adenocarcinoma

  • Adenocarcinoma Of The Epididymis
Epididymis Cancer

  • Malignant Tumor Of Epididymis

  • Malignant Epididymal Tumor

  • Malignant Neoplasm Of Epididymis

  • Neoplasm Of Epididymis
Inflammatory Liposarcoma
Composite Lymphoma

  • Composite Hodgkin And Non-Hodgkin Lymphoma
Sebaceous Adenocarcinoma

  • Sebaceous Carcinoma

  • Adenocarcinoma Of The Sebaceous Gland

  • Malignant Neoplasm Of Sebaceous Gland

  • Malignant Sebaceous Tumor

  • Adenocarcinoma, Sebaceous

  • Malignant Sebaceous Neoplasm

  • Sebaceous Gland Neoplasms
Germ Cell And Embryonal Cancer

  • Germ Cell And Embryonal Neoplasm
Sebaceous Breast Carcinoma
Mediastinal Cancer

  • Mediastinal Neoplasms

  • Mediastinal Tumor

  • Mediastinum Cancer

  • Neoplasm Of Mediastinum

  • Tumour Of Mediastinum

  • Malignant Tumor Of Mediastinum
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Malignant Biphasic Mesothelioma

  • Mesothelioma, Biphasic, Malignant

  • Mixed Mesothelioma
Myeloid Sarcoma

  • Granulocytic Sarcoma

  • Chloroma

  • Extramedullary Myeloid Tumor

  • Sarcoma, Granulocytic

  • Sarcoma Granulocytic

  • Sarcoma, Myeloid

  • Myelosarcoma

  • Myeloid Sarcoma Disease

  • Myeloid Sarcoma Nos

  • Myeloid Sarcoma Without Mention Of Remission
Mucinous Tubular And Spindle Renal Cell Carcinoma

  • Mucinous Tubular And Spindle Cell Renal Carcinoma
Glioblastoma Classical Subtype
Germ Cell Cancer

  • Malignant Germ Cell Tumor

  • Neoplasms, Germ Cell And Embryonal

  • Germ Cell Neoplasm

  • Germ Cell Tumour

  • Malignant Tumor Of The Germ Cell

  • Neoplasms Germ Cell

  • Malignant Germ Cell Neoplasm
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
Nephrogenic Adenoma Of The Urethra

  • Nephrogenic Adenoma Of Urethra
Pleural Lipoma

  • Lipoma Of Pleura
Thymus Large Cell Carcinoma

  • Large Cell Carcinoma Of The Thymus

  • Thymic Large Cell Neuroendocrine Carcinoma
Medulloblastoma

  • MDB

  • Cpnet

  • Localized Primitive Neuroectodermal Tumor

  • Classic Medulloblastoma

  • Medulloblastoma Predisposition Syndrome

  • Medulloblastoma, Somatic

  • Brain Medulloblastoma

  • Cns Pnet

  • Infratentorial Primitive Neuroectodermal Tumor

  • Neuroectodermal Tumors, Primitive

  • Medulloblastomas

  • Desmoplastic Medulloblastoma

  • Medulloblastoma, With Extensive Nodularity

  • Medulloblastoma Of Unspecified Site

  • Medullomyoblastoma Of Unspecified Site
Paranasal Sinus Lymphoma

  • Lymphoma Of Accessory Sinus

  • Lymphoma Of Paranasal Sinus
Bronchiectasis 1
Benign Peritoneal Mesothelioma

  • Mesothelioma Of Peritoneum

  • Benign Neoplasm Of Mesothelial Tissue Of Peritoneum
Urethral Benign Neoplasm

  • Urethral Neoplasms

  • Neoplasm Of Urethra

  • Neoplasm. Urethra

  • Urethral Neoplasm

  • Urethral Carcinoma

  • Malignant Neoplasm Of Urethra
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05155 FUT4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21343 Fut4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27862 Fut4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FUT4 RGD RGD:619954
Canis familiaris FUT4 VGNC VGNC:56101
Bos taurus FUT4 VGNC VGNC:29150
Mus musculus FUT4 MGD MGI:95594
Others FUT4 NCBI