Poliovirus Receptor/PVR Antibody (YA1485)
(Synonyms: PVR; PVS; Poliovirus receptor; Nectin-like protein 5; NECL-5; CD155)Poliovirus Receptor/PVR Antibody (YA1485) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Poliovirus Receptor/PVR.
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Host:
Rabbit
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Isotype:
IgG
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Application:
FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Conjugation:
Non-conjugated
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Applications
| Application |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:50-1:100 | 1:10000 |
Product Details
Poliovirus Receptor/PVR Antibody (YA1485) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Poliovirus Receptor/PVR.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 60-80 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 45 kDa
Recombinant human CD155 protein
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Poliovirus Receptor/PVR mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration; (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport; (Microbial infection) Acts as a receptor for Pseudorabies virus; (Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Cell membrane; Single-pass type I membrane protein; Secreted; Secreted
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Expression
Induction:Transcriptionally regulated by SHH -
Isoforms & Post-Translational Modification
P15151 has 4 isomers: P15151-1: 45303 Da (predicted); P15151-2: 40125 Da (predicted); P15151-3: 39304 Da (predicted); P15151-4: 42864 Da (predicted).
N-glycosylated. N-glycan at Asn-120: Hex5HexNAc4;Phosphorylated by Src kinases on tyrosine residues in the ITIM motif upon ligation. Interaction with TIGIT is required for Phosphorylation -
Subunit
Can form trans-heterodimers with NECTIN3. The extracellular domain interacts with VTN, CD226 and CD96. The cytoplasmic domain interacts with DYNLT1. Binds with high affinity to TIGIT
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SwissProt ID
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Synonyms
PVR; PVS; Poliovirus receptor; Nectin-like protein 5; NECL-5; CD155
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Research Field
Immunology
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