PVR - PVR cell adhesion molecule Gene

Homo sapiens

Also known as PVS; HVED; CD155; NECL5; TAGE4; Necl-5

Gene ID: 5817 | Gene type: protein coding

About PVR

Cytogenetic location: 19q13.31 Genomic coordinates (GRCh38): 19:44,643,910-44,666,162 (from NCBI)

This gene has 6 transcripts (splice variants), 600 orthologues and 14 paralogues. Ubiquitous expression in adrenal (RPKM 7.2), placenta (RPKM 6.6) and 25 other tissues.

Summary

The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein LIGHT chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

PVR Products(4)

mRNA	Protein	Name
NM_001135768.3	NP_001129240.1	poliovirus receptor isoform beta precursor
NM_001135769.3	NP_001129241.1	poliovirus receptor isoform gamma precursor
NM_001135770.4	NP_001129242.2	poliovirus receptor isoform delta precursor
NM_006505.5	NP_006496.4	poliovirus receptor isoform alpha precursor

PVR Protein Structure

V-set

C2-set_2

0
100
200
300
417 a.a.

Protein Preferred Names

Protein Names

poliovirus receptor

nectin-like protein 5

Recombinant PVR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7401	PVR/CD155 Protein, Human (HEK293, Fc)	P15151 (W21-N343)	≥95%
HY-P7402	PVR/CD155 Protein, Human (HEK293, His)	P15151 (W21-N343)	≥95%
HY-P70807	PVR/CD155 Protein, Human (HEK293, His)	NP_006496 (W21-N343)	≥95%
HY-P71114	PVR/CD155 Protein, Human (HEK 293, Fc)	P15151 (W21-N343)	≥95%
HY-P74611	PVR/CD155 Protein, Human (343a.a, HEK293, His)	P15151 (M1-N343)	≥95%
HY-P74612	PVR/CD155 Protein, Human (343a.a, HEK293, hFc)	P15151 (M1-N343)	≥95%
HY-P75614	PVR/CD155 Protein, Human (HEK293)	P15151 (W21-N343)	≥95%
HY-P75615	PVR/CD155 Protein, Human (Biotinylated, 343a.a, HEK293, His-Avi)	P15151 (M1-N343)	≥95%
HY-P75616	PVR/CD155 Protein, Human (Biotinylated, HEK293, His)	P15151 (M1-N343)	≥95%
HY-P78082	PVR/CD155 Protein, Human (Biotinylated, HEK293, Fc-Avi)	P15151 (W21-N343)	≥95%
HY-P78084	PVR/CD155 Protein, Human (Biotinylated, HEK293, His-Avi)	P15151 (W21-N343)	≥95%
HY-P78400	PVR/CD155 Protein, Human (HEK293, mFc)	P15151 (W21-N343)	≥95%
HY-P78402	PVR/CD155 Protein, Human (HEK293, His-Avi)	P15151 (W21-N343)	≥95%

Related Diseases

Diseases

Alias

Poliomyelitis

Polio

Infantile Paralysis

Paralytic Poliomyelitis

Poliomyelitis, Paralytic

Bulbar Polio

Poliomyelitis, Bulbar

Bulbar Poliomyelitis

Cleft Lip/Palate-Ectodermal Dysplasia Syndrome

Orofacial Cleft 7	Zlotogora-Ogur Syndrome
CLPED1	Ectodermal Dysplasia, Margarita Island Type
Ed4	Cleft Lip-Palate-Ectodermal Dysplasia Syndrome
Cleft Lip/Palate-Syndactyly-Pili Torti Syndrome	Syndactyly-Ectodermal Dysplasia-Cleft/Lip Palate
Ectodermal Dysplasia 4	Ectodermal Dysplasia Margarita Type
Ectodermal Dysplasia, Type 4	Ectodermal Dysplasia, Cleft Lip And Palate, Mental Retardation, And Syndactyly
Margarita Type Of Ectodermal Dysplasia	Zlotogora-Zilberman-Tenenbaum Syndrome
Ectd4	Ectodermal Dysplasia 4, Hair/Nail Type
EDMI	Ectodermal Dysplasia Type 4
Margarita Island Ectodermal Dysplasia	Syndactyly-Ectodermal Dysplasia-Cleft Lip/Palate
Non-Syndromic Orofacial Cleft 7	OFC7
Non-Syndromic Cleft Lip/Palate 7	Non-Syndromic Cleft Lip With Or Without Cleft Palate 7

Postpoliomyelitis Syndrome

Postpolio Syndrome	Post-Polio Syndrome
Post Polio Syndrome	Polio Late Effects
Post-Polio Muscular Atrophy	Post-Polio Sequelae
Post-Poliomyelitic Syndrome	Postpolio Sequelae
Postpoliomyelitic Syndrome	Postpoliomyelitis Sequelae

Acute Flaccid Myelitis

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Motor Neuron Disease

Anterior Horn Cell Disease	Motor Neuron Diseases
Mnd - [Motor Neurone Disease]	Lou Gehrig Disease
Creeping Palsy	Creeping Paralysis
Bulbar Motor Neuron Disease	Bulbar Syndrome
Anterior Horn Cell Disorder	Hereditary Motor Neuron Disease

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14252A	Milrinone lactate		/	Unkown

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11473	PVR Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PVR	RGD	RGD:3813
Felis catus	PVR	VGNC	VGNC:69186
Mus musculus	PVR	MGD	MGI:107741
Canis familiaris	PVR	VGNC	VGNC:82568
Macaca fascicularis	PVR	NCBI
Macaca mulatta	PVR	NCBI
Others	PVR	NCBI

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