TSPO - translocator protein Gene

Also Known as DBI; IBP; MBR; PBR; PBS; BPBS; BZRP; PKBS; PTBR; mDRC; pk18; TSPO1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 706

About TSPO

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:43,151,559-43,163,242 (from NCBI)

This gene has 6 transcripts (splice variants), 206 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 105.6), fat (RPKM 61.4) and 20 other tissues.

Summary

Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of Cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the Other variants encode the same protein. [provided by RefSeq, Feb 2012]

TSPO Products (3)

mRNA	Protein	Name
NM_000714.6	NP_000705.2	translocator protein
NM_001256530.1	NP_001243459.1	translocator protein
NM_001256531.1	NP_001243460.1	translocator protein

TSPO Protein Structure

TspO_MBR

0
100
169 a.a.

Protein Preferred Names	Protein Names
translocator protein	benzodiazepine peripheral binding site

TSPO Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TSPO	P30536	NCR3LG1	Homo sapiens	Q68D85	Y2H Array	32296183
Intra	TSPO	P30536	NCR3LG1	Homo sapiens	Q68D85	Y2H Prey Pooling	32296183
Intra	TSPO	P30536	NCR3LG1	Homo sapiens	Q68D85	Validated Y2H	32296183
Intra	TSPO	P30536	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	TSPO	P30536	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	TSPO	P30536	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	TSPO	P30536	LYPD5	Homo sapiens	Q6UWN5	Validated Y2H	32296183
Intra	TSPO	P30536	LYPD5	Homo sapiens	Q6UWN5	Y2H Prey Pooling	32296183
Intra	TSPO	P30536	LYPD5	Homo sapiens	Q6UWN5	Y2H Array	32296183
Intra	TSPO	P30536	LEUTX	Homo sapiens	A8MZ59	Y2H Prey Pooling	32296183
Intra	TSPO	P30536	LEUTX	Homo sapiens	A8MZ59	Y2H Array	32296183
Intra	TSPO	P30536	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	TSPO	P30536	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TSPO	P30536	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TSPO	P30536	AMIGO1	Homo sapiens	Q86WK6	Y2H Prey Pooling	32296183
Intra	TSPO	P30536	AMIGO1	Homo sapiens	Q86WK6	Y2H Array	32296183
Intra	TSPO	P30536	AMIGO1	Homo sapiens	Q86WK6	Validated Y2H	32296183
Intra	TSPO	P30536	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	TSPO	P30536	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	TSPO	P30536	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	TSPO	P30536	CLEC10A	Homo sapiens	Q8IUN9	Validated Y2H	32296183
Intra	TSPO	P30536	CLEC10A	Homo sapiens	Q8IUN9	Y2H Prey Pooling	32296183
Intra	TSPO	P30536	CLEC10A	Homo sapiens	Q8IUN9	Y2H Array	32296183
Intra	TSPO	P30536	PVR	Homo sapiens	P15151	Y2H Array	32296183
Intra	TSPO	P30536	PVR	Homo sapiens	P15151	Y2H Prey Pooling	32296183
Intra	TSPO	P30536	KCNF1	Homo sapiens	Q9H3M0	Y2H Prey Pooling	32296183
Intra	TSPO	P30536	KCNF1	Homo sapiens	Q9H3M0	Validated Y2H	32296183
Intra	TSPO	P30536	KCNF1	Homo sapiens	Q9H3M0	Y2H Array	32296183
Intra	TSPO	P30536	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	25416956
Intra	TSPO	P30536	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	TSPO	P30536	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	TSPO	P30536	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	25416956
Intra	TSPO	P30536	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	TSPO	P30536	TMEM9	Homo sapiens	Q9P0T7	Validated Y2H	32296183
Intra	TSPO	P30536	TMEM9	Homo sapiens	Q9P0T7	Y2H Array	32296183
Intra	TSPO	P30536	TMEM9	Homo sapiens	Q9P0T7	Y2H Prey Pooling	32296183
Intra	TSPO	P30536	ICAM3	Homo sapiens	P32942	Y2H Prey Pooling	32296183
Intra	TSPO	P30536	ICAM3	Homo sapiens	P32942	Validated Y2H	32296183
Intra	TSPO	P30536	ICAM3	Homo sapiens	P32942	Y2H Array	32296183
Intra	TSPO	P30536	CRABP1	Homo sapiens	P29762	Anti Tag CoIP	33961781
Intra	TSPO	P30536	CRABP1	Homo sapiens	P29762	Anti Tag CoIP	28514442
Intra	TSPO	P30536	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	TSPO	P30536	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	TSPO	P30536	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

TSPO Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82040	PBR Antibody (YA1785)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse
HY-P82040A	PBR Antibody (YA1785)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse
HY-P87004	PBR Antibody (YA6697)	WB, ICC/IF, IF-Tissue, IHC-P, IP, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hepatic Encephalopathy	Encephalopathy, Hepatic Portal-Systemic Encephalopathy Hepatoencephalopathy He - [Hepatic Encephalopathy] Hepatic Encephalopathy Nos Hepatic Encephalopathy, Stage Unspecified Hepatic Coma Hepatocerebral Encephalopathy Hepatocerebral Intoxication
Generalized Anxiety Disorder	Anxiety Generalized
Hepatic Coma	Hepatic Encephalopathy Hepatocerebral Intoxication
Panic Disorder	Panic Anxiety Syndrome Panic Panic Disorder 1 Episodic Paroxysmal Anxiety Disorder
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Temporal Lobe Epilepsy	Epilepsy, Temporal Lobe Epilepsy Temporal Lobe
Amnestic Disorder	Amnesia Amnestic Syndrome Korsakoff'S Psychosis Or Syndrome Amnesic Syndrome Amnestic Disorder In Conditions Classified Elsewhere Korsakoff Psychosis Or Syndrome, Nonalcoholic Nonalcoholic Organic Amnesic Syndrome Organic Amnesic Syndrome
Focal Epilepsy	Partial Epilepsy Epilepsies, Partial Localisation-Related Epilepsy
Fibromyalgia	Diffuse Myofascial Pain Syndrome Fibromyalgia Syndrome Fibromyalgia-Fibromyositis Syndrome Fibromyositis Fibrositis Fms Myofascial Pain Syndrome Myofascial Pain Syndromes
Withdrawal Disorder	Withdrawal Syndrome Substance Withdrawal Syndrome
Encephalitis	Mumps Encephalitis Mumps Meningoencephalitis Herpes Simplex Neuroinvasion Herpetic Encephalitis Herpetic Encephalopathy Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis Encephalitis Due To Herpesviridae Encephalitis Due To Herpesvirus Herpes Encephalitis Herpesviral Encephalitis Herpes Simplex Encephalitis Hsv - [Herpes Simplex Virus] Encephalitis Herpes Virus Encephalitis Simian B Disease Simian B Disorder Encephalitis Nec Idiopathic Encephalitis
Cerebrovascular Disease	Cerebrovascular Disorder Cerebrovascular Accident Cerebrovascular Disorders Cva Stroke
Stiff-Person Syndrome	SPS Stiff-Man Syndrome Stiff Man Syndrome Stiff Person Syndrome Moersch-Woltman Syndrome Sms Stiff-Trunk Syndrome Morsch Woltman Syndrome Stiff Person Syndrome And Related Disorders Stiff Person Spectrum Disorder Classic Stiff Person Syndrome Classic Sps Focal Stiff Limb Syndrome Focal Stiff-Person Syndrome Stiff Leg Syndrome Progressive Encephalomyelitis With Rigidity
Wernicke Encephalopathy	Wernicke'S Encephalopathy Wernicke'S Disease Encephalopathy, Wernicke'S Wernicke-Korsakoff Syndrome Encephalopathy Due To Vitamin B1 Deficiency Wernicke Disease Wernicke Syndrome
Schizophrenia 14	Sczd14 Schizophrenia, Susceptibility To, 14 Schizophrenia Susceptibility Locus, Chromosome 2q32-Related
Olivopontocerebellar Atrophy	Thomas Syndrome Olivopontocerebellar Atrophies Dejerine-Thomas Syndrome Thomas' Syndrome Wadia-Swami Syndrome Opca Potter Sequence-Cleft Lip/Palate-Cardiopathy Syndrome Spinocerebellar Ataxia Type 2
Separation Anxiety Disorder	Separation Anxiety Disorder Of Childhood
Status Epilepticus	Grand Mal Status Epilepticus Grand Mal Status Gcse Generalized Convulsive Status Epilepticus Se Epilepsy With Status Epilepticus
Torticollis	Contracture Of Neck Wry Neck Wry Neck/Torticollis
Beriberi	Thiamine Deficiency Vitamin B1 Deficiency Aneurin Deficiency Thiamine Vitamin Deficiency Beriberi Nos Beriberi Due To Vitamin B1 Deficiency Beriberi Due To Thiamine Vitamin Deficiency Kakkè
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Multiple System Atrophy 1	Multiple System Atrophy Shy-Drager Syndrome Msa MSA1 Multiple System Atrophy 1, Susceptibility To Sporadic Olivopontocerebellar Atrophy Multisystem Atrophy Msa1, Susceptibility To Multiple System Atrophy, Susceptibility To Opca Progressive Autonomic Failure With Multiple System Atrophy Sds
Adjustment Disorder	Adjustment Reaction Adjustment Disorders Adjustment Disease Brief Situational Non-Psychotic Disorder Adaptation Reaction Nos Emotional Crisis Situational Disorder Situational Disturbance Situational Maladjustment Situational Reaction Situational Reaction With Maladjustment Transient Situational Disturbance
Childhood Absence Epilepsy	Pyknolepsy Petit Mal Epilepsy Absence Seizures Absence Seizure Petit Mal Seizure Absence Epilepsy, Childhood Pykno-Epilepsy Epilepsy, Absence Absence Epilepsy Pycnolepsy
Epilepsy, Idiopathic Generalized	Idiopathic Generalized Epilepsy Generalised Epilepsy Epilepsy, Generalized EIG Ige Epilepsy, Idiopathic Generalized, Susceptibility To, 1 Epilepsy, Idiopathic Generalized 1 Epilepsy, Idiopathic Generalized, Susceptibility To Epilepsy, Idiopathic, Generalized Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 1
Anterograde Amnesia	Amnesia, Anterograde
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Flying Phobia	Aerophobia
Machado-Joseph Disease	SCA3 MJD Spinocerebellar Ataxia 3 Azorean Disease Spinocerebellar Ataxia Type 3 Spinocerebellar Atrophy Azorean Neurologic Disease Spinopontine Atrophy Nigrospinodentatal Degeneration Spinocerebellar Atrophy Iii Spinocerebellar Atrophy Type 3 Azorean Ataxia Azorean Disease Of The Nervous System Machado Disease Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia Disease, Machado-Joseph Ataxia, Spinocerebellar
Angelman Syndrome	AS Happy Puppet Syndrome Happy Puppet Syndrome, Formerly Puppetlike Syndrome
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Brain Cancer	Adult Brain Tumor Malignant Neoplasm Of Brain Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Mild Cognitive Impairment
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Huntington Disease	Huntington'S Disease Huntington Chorea Huntington'S Chorea HD Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Chronic Granulomatous Disease	Cgd Granulomatous Disease, Chronic Autosomal Recessive Chronic Granulomatous Disease X-Linked Chronic Granulomatous Disease Bridges-Good Syndrome Congenital Dysphagocytosis Quie Syndrome Chronic Septic Granulomatosis Chronic Granulomatous Disorder Granulomatous Disease Chronic Granulomatous Disease, Chronic, X-Linked
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15527	Emapunil	Inhibitor	99.94%	Phase 2
HY-153248	PBR28		98.91%	Phase 2
HY-111191	ONO-2952		99.51%	Phase 2
HY-122607	DPA-714		99.86%	Phase 2
HY-141804	ER176		99.77%	Phase 2
HY-19854	TRO-40303		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (21)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19567	PK 11195	Inhibitor	99.91%	Unkown
HY-400882	Tosylate-DPA-714	Ligand	98.78%	Unkown
HY-148833	MDM2-p53-IN-16	Inhibitor	99.08%	Unkown
HY-150407	TSPO ligand-1	Inducer	98.0%	Unkown
HY-RS15177	TSPO Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W782122	Photoclick cholesterol		99.9%	Unkown
HY-111191A	(R)-ONO-2952		99.81%	Unkown
HY-150409	TSPO ligand-2	Ligand	99.63%	Unkown
HY-169964	TSPO/Carbonic Anhydrase Modulator 1	Modulator	/	Unkown
HY-147225	TSPO Ligand-Linker Conjugates 1	Activator	/	Unkown
HY-150410	TSPO ligand-3		/	Unkown
HY-158408	NZ-66		/	Unkown
HY-172534	BPN-01	Substrate	/	Unkown
HY-175340	Kv7.2/Kv7.3 activator-3	Activator	/	Unkown
HY-186105A	(-)-P7C3-S243	Inhibitor	/	Unkown
HY-RS15178	TSPO2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W634748	Desalkylgidazepam	Agonist	/	Unkown
HY-W667746	DPA-713	Ligand	/	Unkown
HY-RS16721	Tspo Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23157	Tspo Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-122607S	DPA-714-d10		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TSPO	RGD	RGD:2228
Mus musculus	TSPO	MGD	MGI:88222
Macaca mulatta	TSPO	VGNC	VGNC:84537
Canis familiaris	TSPO	VGNC	VGNC:54552
Bos taurus	TSPO	VGNC	VGNC:49066
Others	TSPO	NCBI