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CD370 Antibody (YA4342)(PBS only)

(Synonyms: CLEC9A; DNGR1; DNGR-1; UNQ9341)

CD370 Antibody (YA4342) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD370.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2b

  • Application:

    ICC/IF, FC, ELISA

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • CD370 Antibody (YA4342)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:200 1:200-1:400 1:10000

Product Details

Description

CD370 Antibody (YA4342) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD370.

  • Host Mouse
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 27 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 27 kDa
Immunogen

Purified recombinant fragment of human CD370 (AA: extra 57-241) expressed in E. Coli.

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG2b

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    CD370 functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner

  • Subcellular Localization

    Membrane; Single-pass type II membrane protein

  • Expression


    Tissue_specificity:In peripheral blood highly restricted on the surface of BDCA31 (+) dendritic cells and on a small subset of CD14 (+) and CD16 (-) monocytes

  • Subunit

    Homodimer

  • SwissProt ID

    Q6UXN8

  • Gene ID
    283420 [NCBI]
  • Synonyms

    CLEC9A; DNGR1; DNGR-1; UNQ9341

CD370 Antibody (YA4342)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • CD370 Antibody (YA4342)(PBS only) Product Image
    1/16
  • CD370 Antibody (YA4342)(PBS only) Product Image