CD47 Antibody (YA7717)
(Synonyms: CD47, MER6, Leukocyte surface antigen CD47, Antigenic surface determinant protein OA3, Integrin-associated protein, Protein MER6, IAP)Based on 1 Customer Validation
CD47 Antibody (YA7717) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD47.
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Host:
Rabbit
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Isotype:
IgG
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Application:
FC, ICC/IF
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Reactivity :
Human
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Formulation:
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:50-100 | 1:50-200 |
Product Details
CD47 Antibody (YA7717) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD47.
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Host Rabbit
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Clonality Recombinant
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 33 kDa;
KLH conjugated synthetic peptide derived from human CD47
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD47 is a glycoprotein that was first identified in 1990 as a protein that associates with integrins, hence its original name integrin-associated protein. CD47 interacts with SIRPα (CD172a or SHPS-1) and its family member SIRPγ, CD47 also interacts with integrins and secreted glycoprotein extracellular matrix protein thrombospondin-1 (TSP-1) . Signaling through the CD47/SIRPα axis plays a role in various homeostatic processes, such as maintenance of erythrocytes, innate immune cells and T cells. Moreover, cancer cells and virus-infected and bacteria-infected cells can upregulate CD47 protein expression to prevent immune-mediated elimination.
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Subcellular Localization
Cell membrane
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Expression
Tissue_Specificity: Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. Macrophages (PubMed:39121194)
Induction: Induced in pulmonary artery and lung parenchyma following injury or stress (PubMed:27742621). Expression in arteries increases in normal aging (PubMed:32679764) -
Isoforms & Post-Translational Modification
Q08722 has four isomers: Q08722-1: 35214 Da (predicted); Q08722-2: 31743 Da (predicted); Q08722-3: 33192 Da (predicted); Q08722-4: 33845 Da (predicted).
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Subunit
Monomer (PubMed:18657508)
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SwissProt ID
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Synonyms
CD47, MER6, Leukocyte surface antigen CD47, Antigenic surface determinant protein OA3, Integrin-associated protein, Protein MER6, IAP
Documentation
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