CD62L Antibody (YA4693)
(Synonyms: TQ1; LAM1; LEU8; LNHR; LSEL; CD62L; LYAM1; PLNHR; LECAM1; L-selectin; LECAM-1; SELL; LAM-1; TQ-1; MEL-14; CD62L nanobody; )
Based on 1 Customer Validation
CD62L Antibody (YA4693) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD62L.
-
Host:
Mouse
-
Isotype:
IgG
-
Application:
ELISA, FC
-
Reactivity :
Human
-
Formulation:
Supplied in Phosphate-buffered solution.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
|
FC
FC: Flow Cytometry
|
|---|---|---|
| Dilution Ratio | 1:5000-100000 | 1-2μg/Test |
Product Details
CD62L Antibody (YA4693) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD62L.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman
Purified recombinant Human CD62L
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in Phosphate-buffered solution.
-
Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
CD62L (L-selectin, SELL) is a leukocyte adhesion molecule that primarily mediates the homing of immune cells to lymph nodes and the rolling of cells along blood vessel walls. CD62L is a key marker for distinguishing between naive T cells, central memory T cells, and effector memory T cells, and it plays a significant role in research regarding T-cell immunological memory, vaccine development, CAR-T cell engineering, inflammatory cell trafficking, and immune cell differentiation.
-
Subcellular Localization
Cell membrane; Single-pass type I membrane protein
-
Expression
Tissue_specificity:Expressed in B-cell lines and T-lymphocytes -
Isoforms & Post-Translational Modification
CD62L has 2 isomers: P14151-1: 42187 Da (predicted); P14151-2: 43618 Da (predicted).
N-glycosylated -
Subunit
Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding
-
SwissProt ID
-
Synonyms
TQ1; LAM1; LEU8; LNHR; LSEL; CD62L; LYAM1; PLNHR; LECAM1; L-selectin; LECAM-1; SELL; LAM-1; TQ-1; MEL-14; CD62L nanobody;
Documentation
References
[1]. Bernimoulin MP, et al. Molecular basis of leukocyte rolling on PSGL-1. Predominant role of core-2 O-glycans and of tyrosine sulfate residue 51. J Biol Chem. 2003 Jan 3;278(1):37-47. [Content Brief]
[2]. Mehta-D'souza P, et al. Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force. J Biol Chem. 2017 Feb 10;292(6):2510-2518. [Content Brief]
[3]. Wedepohl S, et al. Reducing Macro- and Microheterogeneity of N-Glycans Enables the Crystal Structure of the Lectin and EGF-Like Domains of Human L-Selectin To Be Solved at 1.9 Å Resolution. Chembiochem. 2017 Jul 4;18(13):1338-1345. [Content Brief]
Powered by Bioz
