SELL - selectin L Gene
Also Known as TQ1; LAM1; LEU8; LNHR; LSEL; CD62L; LYAM1; PLNHR; LECAM1
Species: Homo sapiens
About SELL
This gene has 7 transcripts (splice variants), 86 orthologues and 39 paralogues. Biased expression in lymph node (RPKM 120.3), spleen (RPKM 87.6) and 5 other tissues.
Summary
This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
SELL Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_000655.5 | NP_000646.3 | L-selectin precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables calcium ion binding |
IDA
IDA: Inferred from direct assay
|
28011641 | GOA |
| enables oligosaccharide binding |
IMP
IMP: Inferred from mutant phenotype
|
28011641 | GOA |
| enables protease binding |
IPI
IPI: Inferred from physical interaction
|
17548643 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
18606703 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules |
IMP
IMP: Inferred from mutant phenotype
|
28011641 | GOA |
| involved in leukocyte tethering or rolling |
IMP
IMP: Inferred from mutant phenotype
|
28011641 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
2663882 | GOA |
SELL Protein Structure
Lectin_C: Lectin C-type domain (60 - 169)
EGF: EGF-like domain (173 - 202)
Sushi: Sushi repeat (SCR repeat) (218 - 267)
Sushi: Sushi repeat (SCR repeat) (290 - 329)
- 0
- 100
- 200
- 300
- 385 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
L-selectin |
|
Recombinant SELL Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P74767 | L-selectin/CD62L Protein, Human (CHO, His) | P14151 (D29-N332) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P74768 | L-selectin/CD62L Protein, Human (HEK293, His) | P14151 (W39-N332) | ≥ 95%, as determined by reducing SDS-PAGE. |
SELL Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P811085 | CD62L Antibody | WB, IHC-P | Human, Mouse, Rat |
| HY-P85001 | CD62L Antibody (YA4693) | ELISA, FC | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Arthus Reaction |
|
|
| Cryptococcosis |
|
|
| Leukocyte Adhesion Deficiency, Type I |
|
|
| Boutonneuse Fever |
|
|
| Granulocytopenia |
|
|
| Lymphopenia |
|
|
| Bronchopulmonary Dysplasia |
|
|
| Cohen Syndrome |
|
|
| Leukostasis |
|
|
| Venous Insufficiency |
|
|
| Plummer'S Disease |
|
|
| Vasculitis |
|
|
| Type 1 Diabetes Mellitus 23 |
|
|
| Common Variable Immunodeficiency |
|
|
| Kawasaki Disease |
|
|
| Polyarteritis Nodosa |
|
|
| Extrinsic Allergic Alveolitis |
|
|
| Brucellosis |
|
|
| Peritonitis |
|
|
| Graves' Disease |
|
|
| Leishmaniasis |
|
|
| Coronary Stenosis |
|
|
| Pre-Eclampsia |
|
|
| Alcoholic Hepatitis |
|
|
| Toxicodendron Dermatitis |
|
|
| Bacterial Infectious Disease |
|
|
| Asthma |
|
|
| Immunodeficiency 65 |
|
|
| Human Immunodeficiency Virus Infectious Disease |
|
|
| Hyper Ige Syndrome |
|
|
| Adult Respiratory Distress Syndrome |
|
|
| Inflammatory Bowel Disease |
|
|
| Primary Cutaneous T-Cell Non-Hodgkin Lymphoma |
|
|
| Proteasome-Associated Autoinflammatory Syndrome 1 |
|
|
| Allergic Disease |
|
|
| Rheumatoid Arthritis |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Myocardial Infarction |
|
|
| Mycobacterium Tuberculosis 1 |
|
|
| T Cell Deficiency |
|
|
| Immune Deficiency Disease |
|
|
| Dermatitis, Atopic |
|
|
| Iga Glomerulonephritis |
|
|
| Combined Immunodeficiency |
|
|
| Listeriosis |
|
|
| Hydronephrosis |
|
|
| Systemic Lupus Erythematosus |
|
|
| B-Cell Expansion With Nfkb And T-Cell Anergy |
|
|
| Behcet Syndrome |
|
|
| Immunodeficiency 49 |
|
|
| Thrombocytopenia |
|
|
| Diabetes Mellitus |
|
|
| Lymphoma, Non-Hodgkin, Familial |
|
|
| Colorectal Cancer |
|
|
| Skin Disease |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
| Bronchiectasis 1 |
|
|
| Primary Biliary Cholangitis |
|
|
| Sezary'S Disease |
|
|
| Leukemia, Acute Lymphoblastic |
|
|
| Myelodysplastic Syndrome |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Nervous System Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | SELL | VGNC | VGNC:54991 |
| Mus musculus | SELL | MGD | MGI:98279 |
| Macaca mulatta | SELL | VGNC | VGNC:100138 |
| Rattus norvegicus | SELL | RGD | RGD:3655 |
| Felis catus | SELL | VGNC | VGNC:64983 |
| Others | SELL | NCBI |