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CD64 Antibody (YA3771)(PBS only)

(Synonyms: FCGR1A; FCRI; CD64A; IGFR1)

CD64 Antibody (YA3771) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD64.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG

  • Application:

    IHC-P, FC, ELISA

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • CD64 Antibody (YA3771)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
FC Info
FC: Flow Cytometry
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:200-1:1000 1:200-1:400 1:10000

Product Details

Description

CD64 Antibody (YA3771) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD64.

  • Host Mouse
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 43-80 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 43 kDa
Immunogen

Purified recombinant fragment of human CD64 (AA: extra 16-145) expressed in E. Coli.

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    FcγRI (CD64) is a high-affinity receptor for the Fc region of immunoglobulin γ. FcγRI (CD64) is constitutively expressed by monocytes, macrophages, and many myeloid progenitor cells. FcγRI (CD64) plays a role in both innate and adaptive immune responses. FcγRI (CD64) mediates the effector function of IgG on monocytes, thereby triggering antibody-dependent cytotoxicity (ADCC) to kill virus-infected cells.

  • Subcellular Localization

    Cell membrane; Single-pass type I membrane protein

  • Expression


    Tissue_specificity:Monocyte/macrophage specific

  • Isoforms & Post-Translational Modification

    CD64 has 2 isomers: P12314-1: 42632 Da (predicted); P12314-2: 38795 Da (predicted).
    Phosphorylated on serine residues

  • Subunit

    Interacts with IGHG1. Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL. Interacts with HCK and LYN

  • SwissProt ID

    P12314

  • Gene ID
    2209 [NCBI]
  • Synonyms

    FCGR1A; FCRI; CD64A; IGFR1

References

[1]. van Vugt MJ, et al. The FcgammaRIa (CD64) ligand binding chain triggers major histocompatibility complex class II antigen presentation independently of its associated FcR gamma-chain. Blood. 1999 Jul 15;94(2):808-17. [Content Brief]

CD64 Antibody (YA3771)(PBS only) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • CD64 Antibody (YA3771)(PBS only) Product Image