CD72 Antibody (YA4698)
(Synonyms: CD72; B-cell differentiation antigen CD72; Lyb-2; CD72; CD72 nanobody; )CD72 Antibody (YA4698) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD72.
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Host:
Mouse
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Application:
ELISA, FC
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Reactivity :
Human
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Formulation:
Supplied in Phosphate-buffered solution.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:5000-100000 | 1-2μg/Test |
Product Details
Product Properties
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Appearance
Liquid
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Formulation
Supplied in Phosphate-buffered solution.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions. Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling. Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling. Also acts as a ligand for CD5 and thereby plays a critical role in maintaining regulatory T and B-cell homeostasis
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Subcellular Localization
Membrane; Single-pass type II membrane protein
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Expression
Tissue_specificity:Pre-B-cells and B-cells but not terminally differentiated plasma cells -
Subunit
Homodimer; disulfide-linked. Associates with CD5. Interacts (tyrosine phosphorylated) with PTPN6/SHP-1
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SwissProt ID
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Synonyms
CD72; B-cell differentiation antigen CD72; Lyb-2; CD72; CD72 nanobody;
Documentation
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