CDX1+CDX2+CDX4 Antibody (YA5700)

Art. -Nr.: HY-P86008: Data Sheet User Guide for Antibodies
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CDX1+CDX2+CDX4 Antibody (YA5700) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CDX1+CDX2+CDX4.

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100 μL		Angebot einholen

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Beschreibung
Verweise

Beschreibung

CDX1+CDX2+CDX4 Antibody (YA5700) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CDX1+CDX2+CDX4.

Host

Mouse

Clonality

Monoclonal

Species Reactivity

Human

SwissProt ID

P47902 / Q99626 / O14627

Gene ID

1045 [NCBI]

Immunogen

Synthesized peptide derived from human CDX-2 AA range: 150-265

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-400
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-200
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:500-5000

Reinheit	affinity chromatography.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Versand

Shipping with blue ice.

Background

Function：P47902: Plays a role in transcriptional regulation (PubMed:24623306). Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed:24623306). Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA (PubMed:28473536)
Q99626: Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity). Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536)

Subcellular Localization：P47902: Nucleus
Q99626: Nucleus
O14627: Nucleus

Expression：
Tissue_specificity: P47902: Intestinal epithelium
Q99626: Detected in small intestine, colon and pancreas

Isoforms & Post-Translational Modification：P47902 has 2 isomers: P47902-1: 28138 Da (predicted); P47902-2: 14661 Da (predicted).

Subunit：Q99626: Can bind DNA as a monomer or homodimer

Dokumentation

User Guide for Antibodies (1077 KB)

Verweise

[1]. /biology-dictionary/sw-620-cell.html [Content Brief]