CEMIP Antibody (YA8877)
(Synonyms: CEMIP, KIAA1199, EC:3.2.1.35, Hyaluronan binding protein involved in hyaluronan depolymerization, HYBID)
Based on 1 Customer Validation
CEMIP Antibody (YA8877) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CEMIP.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, IP, ELISA
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Reactivity :
human
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Formulation:
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IP
IP: Immunoprecipitation
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1000 | 1-2μg per 100-500μg Total protein | 1:50-3000 |
Product Details
CEMIP Antibody (YA8877) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CEMIP.
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Host Mouse
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Species Reactivityhuman
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Calculated Molecular Weight Predicted band size: 109/150 kDa
OMIM: 608366
A synthesized peptide derived from human CEMIP.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at 2-8°C for 1 year, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
CEMIP mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing
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Subcellular Localization
Nucleus; Cytoplasm; Endoplasmic reticulum; Cell membrane; Membrane, clathrin-coated pit; Secreted
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Expression
Tissue_Specificity: Expressed in dermal and in synovial fibroblasts. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in both ductal carcinoma and invasive breast cancer cells compared with benign epithelial cells (at protein level). Strongly expressed in brain, placenta, prostate, breast, lung and testis. Expressed in fibroblasts, epithelial cells and cancer cells. In ear, it is specifically expressed in inner ear. Expressed in cochlea and vestibule tissues. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in colon adenocarcinomas compared with normal colonic mucosas. Strongly expressed in breast cancer as compared to normal breast tissue.
Induction: Up-regulated by histamine. Up-regulated by the adapter protein complex 1 (AP-1) and NF-kappaB/RELA. Down-regulated by transforming growth factor TGFB1. -
Isoforms & Post-Translational Modification
CEMIP has 2 isoforms, Q8WUJ3-1: amino acid length is 1361, molecular weight is 152998 Da (predicted); Q8WUJ3-2: amino acid length is 992, molecular weight is 110357 Da (predicted).
N-glycosylated; glycosylation is not necessary for HA-binding -
Subunit
Interacts with EPHA2 and ITPR3.
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SwissProt ID
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Synonyms
CEMIP, KIAA1199, EC:3.2.1.35, Hyaluronan binding protein involved in hyaluronan depolymerization, HYBID
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