CEMIP - cell migration inducing hyaluronidase 1 Gene

Also Known as CCSP1; HYBID; TMEM2L; KIAA1199

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57214

About CEMIP

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:80,779,370-80,951,771 (from NCBI)

This gene has 6 transcripts (splice variants), 198 orthologues and 1 paralogue. Biased expression in endometrium (RPKM 32.4), appendix (RPKM 6.2) and 5 other tissues.

Summary

Enables several functions, including clathrin heavy chain binding activity; hyaluronic acid binding activity; and hyalurononglucosaminidase activity. Involved in several processes, including hyaluronan catabolic process; positive regulation of protein phosphorylation; and positive regulation of transport. Located in clathrin-coated endocytic vesicle; endoplasmic reticulum; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

CEMIP Products (3)

mRNA Protein Name
NM_001293298.2 NP_001280227.1 cell migration-inducing and hyaluronan-binding protein precursor
NM_001293304.2 NP_001280233.1 cell migration-inducing and hyaluronan-binding protein precursor
NM_018689.3 NP_061159.1 cell migration-inducing and hyaluronan-binding protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ER retention sequence binding IDA
IDA: Inferred from direct assay
23990668 GOA
enables clathrin heavy chain binding IDA
IDA: Inferred from direct assay
23509262 GOA
enables hyaluronic acid binding IDA
IDA: Inferred from direct assay
23509262 GOA
enables hyalurononglucosaminidase activity IMP
IMP: Inferred from mutant phenotype
23509262 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23990668 GOA
Biological Process GO Annotation Evidence References Source
involved in hyaluronan catabolic process IMP
IMP: Inferred from mutant phenotype
23509262 GOA
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
23990668 GOA
involved in positive regulation of peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
23990668 GOA
involved in positive regulation of protein kinase C activity IDA
IDA: Inferred from direct assay
23990668 GOA
involved in positive regulation of protein targeting to membrane IDA
IDA: Inferred from direct assay
23990668 GOA
involved in positive regulation of release of sequestered calcium ion into cytosol IDA
IDA: Inferred from direct assay
23990668 GOA
involved in sensory perception of sound IMP
IMP: Inferred from mutant phenotype
14577002 GOA
Cellular Component GO Annotation Evidence References Source
located in clathrin-coated endocytic vesicle IDA
IDA: Inferred from direct assay
23509262 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
16157444 GOA
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
14577002 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
23990668 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
23509262 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CEMIP Protein Structure

G8

G8: G8 domain (46 - 165)

Mucin2_WxxW

Mucin2_WxxW: Mucin-2 protein WxxW repeating region (324 - 403)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1361 a.a.
Protein Preferred Names Protein Names

cell migration-inducing and hyaluronan-binding protein

  • cell migration inducing hyaluronan binding protein

CEMIP Antibodies

Cat. No. Product Name Application Reactivity
HY-P811294 CEMIP Antibody WB, IHC-P Human, Mouse
HY-P89533 CEMIP Antibody (YA8877) WB, IP, ELISA human

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02468 CEMIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02469 CEMIP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19994 Cemip Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26498 Cemip Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CEMIP VGNC VGNC:39099
Macaca mulatta CEMIP VGNC VGNC:71130
Felis catus CEMIP VGNC VGNC:60750
Bos taurus CEMIP VGNC VGNC:27172
Mus musculus CEMIP MGD MGI:2443629
Rattus norvegicus CEMIP RGD RGD:1305254
Others CEMIP NCBI