CEMIP Antibody
(Synonyms: BLVR; BVR; Biliverdin reductase A; BVR A; Biliverdin-IX alpha-reductase)CEMIP Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to CEMIP.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
CEMIP Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to CEMIP.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 180 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 110; 152 kDa
Purified recombinant protein of human CEMIP.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CEMIP mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing
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Subcellular Localization
Nucleus; Cytoplasm; Endoplasmic reticulum; Cell membrane; Membrane, clathrin-coated pit; Secreted
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Expression
Tissue_Specificity: Expressed in dermal and in synovial fibroblasts. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in both ductal carcinoma and invasive breast cancer cells compared with benign epithelial cells (at protein level). Strongly expressed in brain, placenta, prostate, breast, lung and testis. Expressed in fibroblasts, epithelial cells and cancer cells. In ear, it is specifically expressed in inner ear. Expressed in cochlea and vestibule tissues. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in colon adenocarcinomas compared with normal colonic mucosas. Strongly expressed in breast cancer as compared to normal breast tissue.
Induction: Up-regulated by histamine. Up-regulated by the adapter protein complex 1 (AP-1) and NF-kappaB/RELA. Down-regulated by transforming growth factor TGFB1. -
Isoforms & Post-Translational Modification
CEMIP has 2 isoforms, Q8WUJ3-1: amino acid length is 1361, molecular weight is 152998 Da (predicted); Q8WUJ3-2: amino acid length is 992, molecular weight is 110357 Da (predicted).发生 N-糖基化修饰；糖基化对于透明质酸(HA)结合不是必需的CEMIP 存在 2 个异构体，Q8WUJ3-1：氨基酸个数为 1361 个，分子量为 152998 Da (预测)；Q8WUJ3-2：氨基酸个数为 992 个，分子量为 110357 Da (预测)。N-glycosylated; glycosylation is not necessary for HA-binding
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Subunit
Interacts with EPHA2 and ITPR3.
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SwissProt ID
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Synonyms
BLVR; BVR; Biliverdin reductase A; BVR A; Biliverdin-IX alpha-reductase
Documentation
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