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CXCL11 Antibody (YA1769)

(Synonyms: betaR; CXC11; CXCL11; H174; I TAC; IP9; ITAC; SCYB11; SCYB9B)
Customer Review

Based on 1 Customer Validation

CXCL11 Antibody (YA1769) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CXCL11.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, ICC/IF

  • Reactivity :

    Human

  • Formulation:

    Supplied in Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for CXCL11 Antibody (YA1769)
  • CXCL11 Antibody (YA1769) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Related Products:
Top Publications Citing

Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
Dilution Ratio 1:500-1:1000 1:50-1:200

Product Details

Description

CXCL11 Antibody (YA1769) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CXCL11.

  • Host Rabbit
  • Clonality Recombinant, Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 15 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 10 kDa
Species Reactivity Database

Entrez Gene: 6373 Human

SwissProt: O14625 Human

Immunogen

A synthesized peptide derived from human CXCL11 aa20-65/94.

Sensitivity

Endogenous

Purification

Affinity Chromatography

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3104145

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for CXCL11 Antibody (YA1769)
    Western blot analysis of extracts from THP-1(lane 2(20ug) and THP-1(lane 3(40ug) using CXCL11 Antibody (HY-P82024) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P83730, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

Background

  • Function

    CXCL11 is a Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses

  • Subcellular Localization

    Secreted

  • Expression


    Tissue_specificity:High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders

    Induction:By IFNG/IFN-gamma and IFNB1/IFN-beta. Induction by IFNG/IFN-gamma is enhanced by TNF in monocytes, dermal fibroblasts and endothelial cells, and by IL1/interleukin-1 in astrocytes

  • Subunit

    Interacts with TNFAIP6 (via Link domain)

  • SwissProt ID

    O14625

  • Gene ID
    6373 [NCBI]
  • Synonyms

    betaR; CXC11; CXCL11; H174; I TAC; IP9; ITAC; SCYB11; SCYB9B

  • Research Field

    Immunology

CXCL11 Antibody (YA1769) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedchemExpress Validation
     Western blot analysis of extracts from THP-1(lane 2(20ug) and THP-1(lane 3(40ug) using CXCL11 Antibody (HY-P82024) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P83730, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

  • CXCL11 Antibody (YA1769) Product Image
    1/16
  • Experimental Validation Results for CXCL11 Antibody (YA1769)
  • CXCL11 Antibody (YA1769) Product Image
  • Experimental Validation Results for CXCL11 Antibody (YA1769)
    1/1
    MedchemExpress Validation
     Western blot analysis of extracts from THP-1(lane 2(20ug) and THP-1(lane 3(40ug) using CXCL11 Antibody (HY-P82024) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P83730, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
  • Experimental Validation Results for CXCL11 Antibody (YA1769)
  • CXCL11 Antibody (YA1769) Product Image
    MedchemExpress Validation

    Western blot analysis of extracts from THP-1(lane 2(20ug) and THP-1(lane 3(40ug) using CXCL11 Antibody (HY-P82024) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P83730, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

  • CXCL11 Antibody (YA1769) Product Image WB