CXCL11 - C-X-C motif chemokine ligand 11 Gene

Also Known as IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6373

About CXCL11

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:76,033,682-76,036,070 (from NCBI)

This gene has 2 transcripts (splice variants), 88 orthologues and 12 paralogues. Broad expression in appendix (RPKM 6.2), lymph node (RPKM 5.0) and 21 other tissues.

Summary

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

CXCL11 Products (2)

mRNA	Protein	Name
NM_001302123.2	NP_001289052.1	C-X-C motif chemokine 11 isoform 2 precursor
NM_005409.5	NP_005400.1	C-X-C motif chemokine 11 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables CXCR3 chemokine receptor binding	IDA IDA: Inferred from direct assay	12782716	GOA
enables chemokine activity	IDA IDA: Inferred from direct assay	12782716	GOA
enables heparin binding	IMP IMP: Inferred from mutant phenotype	18645041	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18275857	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in T cell chemotaxis	IMP IMP: Inferred from mutant phenotype	18645041	GOA
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	12782716	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	12949249	GOA
involved in chemokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18645041	GOA
involved in chemotaxis	IDA IDA: Inferred from direct assay	12782716	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	12949249	GOA
involved in positive regulation of release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	12782716	GOA
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12782716	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CXCL11 Protein Structure

IL8

0
94 a.a.

Protein Preferred Names	Protein Names
C-X-C motif chemokine 11	beta-R1

CXCL11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CXCL11	O14625	PF4V1	Homo sapiens	P10720	Filter Binding	28381538
Intra	CXCL11	O14625	CCL24	Homo sapiens	O00175	Filter Binding	28381538
Intra	CXCL11	O14625	PF4	Homo sapiens	P02776	SPR	28381538
Intra	CXCL11	O14625	CXCL14	Homo sapiens	O95715	Filter Binding	28381538
Intra	CXCL11	O14625	CCL5	Homo sapiens	P13501	Filter Binding	28381538
Intra	CXCL11	O14625	CCL5	Homo sapiens	P13501	SPR	28381538
Intra	CXCL11	O14625	DPP4	Homo sapiens	P27487	Enzymatic Study	18275857
Intra	CXCL11	O14625	CXCL12	Homo sapiens	P48061	Filter Binding	28381538
Intra	CXCL11	O14625	CXCL12	Homo sapiens	P48061	SPR	28381538
Intra	CXCL11	O14625	CCL13	Homo sapiens	Q99616	Filter Binding	28381538
Intra	CXCL11	O14625	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956
Intra	CXCL11	O14625	CCL26	Homo sapiens	Q9Y258	Filter Binding	28381538

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CXCL11 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7228	I-TAC/CXCL11 Protein, Human (HEK293)	O14625 (F22-F94)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7229	I-TAC/CXCL11 Protein, Human	O14625 (F22-F94)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700042AF	Animal-Free I-TAC/CXCL11 Protein, Human (His)	O14625 (F22-F94)	≥ 95%, as determined by reducing SDS-PAGE.

CXCL11 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82024	CXCL11 Antibody (YA1769)	WB, ICC/IF	Human

Related Diseases

Diseases	Alias
Nasal Cavity Adenocarcinoma	Adenocarcinoma Of Nasal Cavity Adenocarcinoma Of The Nasal Cavity
Nasal Cavity Cancer	Nasal Cavity Carcinoma Malignant Neoplasm Of Nasal Cavities Malignant Tumor Of The Nasal Cavity Cancer Of Nasal Cavity Carcinoma Of Nasal Cavity Malignant Neoplasm Of Nasal Cavity Neoplasm Of Nasal Cavity
Mycosis Fungoides	Mycosis Fungoides Lymphoma Alibert-Bazin Syndrome Granuloma Fungoides Classic Mycosis Fungoides Mycosis Fungoides, Alibert-Bazin Type
American Histoplasmosis	Infection By Histoplasma Capsulatum
Ethmoid Sinus Adenocarcinoma	Adenocarcinoma Of Ethmoid Sinus Adenocarcinoma Of The Ethmoid Sinus
Dermatitis	Eczema Skin Inflammation Inflammatory Dermatosis
Cryoglobulinemia	Cryoimmunoglobulinaemia
Breast Duct Papilloma	Intraductal Papilloma Of Breast Duct Papilloma Of Breast Papilloma Of The Breast
Allergic Contact Dermatitis	Dermatitis, Allergic Contact Contact Dermatitis, Allergic Dermatitis Allergic Contact Allergic Contact Eczema Acd - [Allergic Contact Dermatitis] Allergic Contact Dermatitis, Unspecified Cause Allergic Dermatitis Allergic Eczema Allergy Dermatitis Allergy Eczema Allergic Contact Eczema Due To Clothing Or Footwear Perfume Allergic Contact Dermatitis Allergic Contact Dermatitis Due To Cosmetics Allergic Contact Eczema Due To Cosmetics Or Fragrances Allergic Contact Eczema Due To Dental Materials Allergic Contact Eczema Due To Food Flavours Or Additives Allergic Contact Eczema Due To Hairdressing Products Allergic Contact Eczema Due To Metals Or Metal Salts Allergic Contact Eczema Due To Proteins Allergic Contact Eczema Due To Plastics Or Resin Systems Allergic Contact Eczema Due To Preservatives Or Biocides Allergic Contact Eczema Due To Rubber Chemicals Rubber Dermatitis Allergic Contact Eczema Due To Systemic Medicaments Allergic Contact Eczema Due To Topical Medicaments Allergic Contact Dermatitis Due To Drugs In Contact With Skin
Relapsing-Remitting Multiple Sclerosis	Relapsing-Remitting Ms Relapsing Remitting Multiple Sclerosis Multiple Sclerosis, Relapsing-Remitting Rrms Multiple Sclerosis Relapsing-Remitting
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Nasal Cavity Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Nasal Cavity Squamous Cell Carcinoma Of The Nasal Cavity
Maxillary Sinus Adenocarcinoma	Adenocarcinoma Of Maxillary Sinus Adenocarcinoma Of The Maxillary Sinus
Ethmoid Sinus Cancer	Malignant Neoplasm Of Ethmoidal Sinus Malignant Tumor Of Ethmoid Sinus Malignant Tumor Of Ethmoidal Sinus Neoplasm Of Ethmoidal Sinus
Retroperitoneal Hemangiopericytoma
Sinonasal Undifferentiated Carcinoma	Highly Aggressive Undifferentiated Carcinoma Of The Nasal Cavity And Paranasal Sinuses Snuc
Paranasal Sinus Cancer	Paranasal Sinus Adenoid Cystic Carcinoma Paranasal Sinus Mucoepidermoid Carcinoma Paranasal Sinus Squamous Cell Carcinoma Paranasal Sinus Neoplasms Adenoid Cystic Carcinoma Of Accessory Sinus Adenoid Cystic Carcinoma Of Paranasal Sinus Epidermoid Carcinoma Of The Paranasal Sinus Mucoepidermoid Carcinoma Of Accessory Sinus Paranasal Sinus Adenocarcinoma Squamous Cell Carcinoma Of Paranasal Sinus Paranasal Sinus Neoplasm Adenocarcinoma Of Accessory Sinus
Olmsted Syndrome, X-Linked	OLMSX Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques, X-Linked Ppkmx X-Linked Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques X-Linked Olmsted Syndrome Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques, X-Linked
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Pediculus Humanus Corporis Infestation	Body Louse Infestation Pediculus Corporis Pediculus Humanus Infestation
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Immunodeficiency 27a	IMD27A Autosomal Recessive Ifngr1 Deficiency Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency Autosomal Recessive Msmd Due To Partial Ifngammar1 Deficiency Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency Immunodeficiency 27a, Mycobacteriosis, Autosomal Recessive Ifngr1 Deficiency, Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis, Ar Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar1 Deficiency Msmd Due To Complete Ifngammar1 Deficiency Msmd Due To Complete Interferon Gamma Receptor 1 Deficiency Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 1 Deficiency Familial Disseminated Atypical Mycobacterial Infection Interferon Gamma, Receptor 1, Deficiency Immunodeficiency, Type 27a, Mycobacteriosis, Ar Mycobacterial Disease, Mendelian Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15319	AMG 487	Inhibitor	99.89%	Unkown
HY-139643	CXCR7 antagonist-1	Antagonist	99.85%	Unkown
HY-149055	ACT-777991	Antagonist	99.86%	Unkown
HY-15320	NBI-74330	Antagonist	99.76%	Unkown
HY-139643A	CXCR7 antagonist-1 hydrochloride	Antagonist	99.41%	Unkown
HY-165428	SCH-900875	Inhibitor	98.16%	Unkown
HY-113730	VUF5834	Antagonist	/	Unkown
HY-15319A	(±)-AMG 487	Inhibitor	/	Unkown
HY-RS03385	CXCL11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W505771	Seselin	Inhibitor	99.55%	Unkown
HY-167884	PF-1367550	Inhibitor	/	Unkown
HY-RS16707	Cxcl11 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23142	Cxcl11 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CXCL11	RGD	RGD:727827
Macaca mulatta	CXCL11	VGNC	VGNC:106564
Mus musculus	CXCL11	MGD	MGI:1860203
Felis catus	CXCL11	VGNC	VGNC:78477
Bos taurus	CXCL11	VGNC	VGNC:27847
Others	CXCL11	NCBI