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Cat. No.: HY-P87590

CYFIP1 Antibody (YA7274)

CYFIP1 Antibody (YA7274) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CYFIP1.

For research use only. We do not sell to patients.

Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	FC FC: Flow Cytometry	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence
Dilution Ratio	1:1000-2000	1:50-100	1:50-200

Description

CYFIP1 Antibody (YA7274) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CYFIP1.

Host Rabbit
Clonality Recombinant,Monoclonal
Species Reactivity
Human Predicted Reactivity: Mouse,Rat

Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
Observed Molecular Weight

Observed band size: 130 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 145 kDa

Immunogen

A synthesized peptide derived from human CYFIP1

Sensitivity

Endogenous

Purification

affinity purified by Protein A

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Appearance

Liquid
Formulation

Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

CYFIP1 component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA. Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. May act as an invasion suppressor in cancers
Subcellular Localization

Cytoplasm,Cytoplasm, perinuclear region,Cell projection, lamellipodium,Cell projection, ruffle,Synapse, synaptosome
Isoforms & Post-Translational Modification

Q7L576 has three isomers: Q7L576-1: 145182 Da (predicted); Q7L576-2: 94467 Da (predicted); Q7L576-3: 51534 Da (predicted).
Subunit

Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1
SwissProt ID

Q7L576