DAND5 Antibody (YA8419)(PBS only)

Cat. No.: HY-P88735A: Data Sheet User Guide for Antibodies
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DAND5 Antibody (YA8419) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to DAND5.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

DAND5 Antibody (YA8419) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to DAND5.

Host

Mouse

Molecular Weight

Predicted band size: 18 kDa

Species Reactivity

Human

SwissProt ID

Q8N907

Immunogen

Human recombinant protein fragment corresponding to amino acids 23-189 of human DAND5 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250
FC FC: Flow Cytometry	1:100

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG2a

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Antagonist of the extracellular signaling protein NODAL, which is required for correct left-right patterning during embryonic development (By similarity). Antagonist of BMP and TGF-beta signaling (PubMed:33587337). Independently of its role in left-right axis establishment, plays a role during heart development, possibly through the regulation of TGF-beta/Nodal signaling pathway (By similarity). Displays anti-angiogenic activity by inhibiting endothelial sprouting, migration, and proliferation. Once internalized by endothelial cells, may alter their redox and glycolytic balance (PubMed:33587337)

Subcellular Localization：Secreted

Expression：
Tissue_Specificity: Expressed in the retina, in inner segments of photoreceptors, at or close to the outer plexiform layer and in the ganglion cell layer (at protein level)
Induction: Down-regulation during the establishment of embryonic left-right axis could be due to translation repression, involving BICC1 and possibly DICER1, and/or transcript degradation, involving BICC1 and the CCR4-NOT complex. Attenuated DAND5 expression lifts repression of NODAL and defines leftness by induction of the left lateral plate mesoderm NODAL signaling cascade

Isoforms & Post-Translational Modification：Q8N907: 189 amino acids, molecular weight 20180 Da.

Synonyms

CER2; CERL2; CKTSF1B3; COCO; CRL2; DANTE; GREM3; SP1

Documentation

User Guide for Antibodies (1077 KB)