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Cat. No.: HY-P85582

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DDB1 Antibody (YA5274)

Name: DDB1 Antibody (YA5274)
Brand: MedChemExpress
SKU: HY-P85582
Availability: PreOrder

(Synonyms: Damage specific DNA binding protein 1; Damage-specific DNA-binding protein 1; DDB 1; DDB p127 subunit; Ddb1; DDB1_HUMAN; DDBa; DNA damage binding protein 1; DNA damage-binding protein 1; DNA damage-binding protein a; HBV X-associated protein 1; UV damaged DNA binding factor; UV damaged DNA binding protein 1; UV DDB 1; UV DDB1; UV-damaged DNA-binding factor; UV-damaged DNA-binding protein 1; UV-DDB 1; UV-DDB1; X associated protein 1; XAP 1; XAP-1; XAP1; Xeroderma pigmentosum group E complementing protein; Xeroderma pigmentosum group E-complementing protein; XPCE; XPE; XPE BF; XPE binding factor; XPE-BF; XPE-binding factor.)

DDB1 Antibody (YA5274) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to DDB1.

For research use only. We do not sell to patients.

Host:
Rabbit
Application:
WB, IHC-P, ICC/IF, IP, FC, IF-Tissue
Reactivity :
Human, Mouse, Rat

Formulation:
Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Conjugation:
Non-conjugated

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications
Product Details
Product Properties
- Appearance
- Formulation
- Storage & Stability
- Shipping
Background
Documentation
References
Help & FAQs
Classifications
Bioz

Applications

Application	WB WB: Western Blot	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	IF-Tissue IF-Tissue: Immunofluorescence-Tissue	IHC-P IHC-P: Immunohistochemistry-Paraffin	IP IP: Immunoprecipitation	FC FC: Flow Cytometry
Dilution Ratio	1:2,000	1:50-1:200	1:50-1:200	1:1,000	1:10-1:50	1:1,000

Product Details

Description

DDB1 Antibody (YA5274) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to DDB1.

Host Rabbit
Clonality Monoclonal,Recombinant
Species Reactivity
Human, Mouse, Rat
Observed Molecular Weight

Observed band size: 127 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Immunogen

Recombinant protein within Human DDB1 aa 1040-1140 / 1,140.

Purification

affinity chromatography.

Conjugation

Non-conjugated

Modification

Unmodified

Product Properties

Appearance

Solution
Formulation

Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Background

Function

DNA Damage Binding Protein-1 (DDB1) is a protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively. The ubiquitin–proteasome system is a significant pathway that precisely governs protein stability. Among the Cullin-RING Ligase (CRL) family, a typical CRL4 ligase is composed of a scaffold Cullin (CUL4A or CUL4B) protein, a linker protein-DDB1, a substrate recognition adaptor (DCAF), and a ring protein with intrinsic E3 activity (RBX1 or RBX2) .
Subcellular Localization

Cytoplasm; Nucleus
Isoforms & Post-Translational Modification

Q16531 has 2 isomers: Q16531-1: 126968 Da (predicted); Q16531-2: 50611 Da (predicted).
Phosphorylated by ABL1;Ubiquitinated by CUL4A. Subsequently degraded by ubiquitin-dependent proteolysis;Acetylated, promoting interaction with CUL4 (CUL4A or CUL4B) and subsequent formation of DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes (PubMed:28886238). Deacetylation by SIRT7 impairs the interaction with CUL4 (CUL4A or CUL4B) and formation of DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes (PubMed:28886238)
Subunit

Component of the UV-DDB complex which includes DDB1 and DDB2; the heterodimer dimerizes to give rise to a heterotetramer when bound to damaged DNA (PubMed:16223728, PubMed:16527807, PubMed:19109893, PubMed:22822215, PubMed:9632823).
SwissProt ID

Q16531
Gene ID

1642 [NCBI]
Synonyms

Damage specific DNA binding protein 1; Damage-specific DNA-binding protein 1; DDB 1; DDB p127 subunit; Ddb1; DDB1_HUMAN; DDBa; DNA damage binding protein 1; DNA damage-binding protein 1; DNA damage-binding protein a; HBV X-associated protein 1; UV damaged DNA binding factor; UV damaged DNA binding protein 1; UV DDB 1; UV DDB1; UV-damaged DNA-binding factor; UV-damaged DNA-binding protein 1; UV-DDB 1; UV-DDB1; X associated protein 1; XAP 1; XAP-1; XAP1; Xeroderma pigmentosum group E complementing protein; Xeroderma pigmentosum group E-complementing protein; XPCE; XPE; XPE BF; XPE binding factor; XPE-BF; XPE-binding factor.