DNAJA4 Antibody (YA9743)
(Synonyms: DnaJ (Hsp40) homolog subfamily A member 4, DNAJ A4, MST104, PRO1472)DNAJA4 Antibody (YA9743) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to DNAJA4.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF, IHC-P, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:1000 | 1:100 | 1:1000 | 1:1000 |
Product Details
DNAJA4 Antibody (YA9743) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to DNAJA4.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 45 kDa;
Synthetic peptide within human DNAJA4 (aa 348-397).
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
DNAJA4 is a Co-chaperone for HSPA8/Hsc70. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as a co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV[1][2][3][4].
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Subcellular Localization
Membrane; Lipid-anchor; Cytoplasm; Microsome; Nucleus; Cytoplasm, perinuclear region; Mitochondrion
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Expression
Tissue_specificity:Ubiquitous. Isoform 2 is highly expressed in testis and lung, but detected at low levels in thymus, prostate, colon and liver
Induction:Up-regulated by heat shock -
Isoforms & Post-Translational Modification
P31689 has 2 isomers: P31689-1: 44868 Da (predicted); P31689-2: 37045 Da (predicted).
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Subunit
Identified in a complex with HSPA1B and BAX (PubMed:14752510). Interacts with RNF207 (PubMed:25281747)
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SwissProt ID
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Synonyms
DnaJ (Hsp40) homolog subfamily A member 4, DNAJ A4, MST104, PRO1472
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