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DNAJB2 Antibody (YA8517)(PBS only)

(Synonyms: CMT2T; DSMA5; HSJ-1; HSJ1; HSPF3)

DNAJB2 Antibody (YA8517) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DNAJB2.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    ICC/IF, FC

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • DNAJB2 Antibody (YA8517)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
Dilution Ratio 1:100-250 1:100

Product Details

Description

DNAJB2 Antibody (YA8517) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DNAJB2.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 30.4 kDa
Immunogen

Full length human recombinant protein of human DNAJB2 produced in HEK293T cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    DNAJB2 functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins. Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins[1][2][3][4][5][6][7][8][9].

  • Subcellular Localization

    Cytoplasm,Nucleus,Endoplasmic reticulum membrane

  • Expression


    Tissue_Specificity: More abundantly expressed in neocortex, cerebellum, spinal cord and retina where it is expressed by neuronal cells (at protein level) (PubMed:12754272, PubMed:1599432). Detected at much lower level in non-neuronal tissues including kidney, lung, heart, skeletal muscle, spleen and testis (at protein level) (PubMed:12754272, PubMed:1599432). Isoform 1 is more abundant in neocortex and cerebellum compared to isoform 2 (at protein level) (PubMed:12754272)

  • Isoforms & Post-Translational Modification

    P25686 has two isomers: P25686-3: 35580 Da (predicted); P25686-2: 30569 Da (predicted).
    Ubiquitinated by STUB1; does not lead to proteasomal degradation

  • Subunit

    Interacts with HSP70 (HSPA1A or HSPA1B) (PubMed:21625540, PubMed:22219199)

  • SwissProt ID

    P25686

  • Synonyms

    CMT2T; DSMA5; HSJ-1; HSJ1; HSPF3

DNAJB2 Antibody (YA8517)(PBS only) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • DNAJB2 Antibody (YA8517)(PBS only) Product Image