DNAJB2 Antibody (YA8517)
(Synonyms: CMT2T; DSMA5; HSJ-1; HSJ1; HSPF3)DNAJB2 Antibody (YA8517) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DNAJB2.
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Host:
Mouse
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Isotype:
IgG1
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Application:
ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:100-250 | 1:100 |
Product Details
DNAJB2 Antibody (YA8517) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DNAJB2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 30.4 kDa
Full length human recombinant protein of human DNAJB2 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
DNAJB2 functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins. Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins[1][2][3][4][5][6][7][8][9].
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Subcellular Localization
Cytoplasm,Nucleus,Endoplasmic reticulum membrane
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Expression
Tissue_Specificity: More abundantly expressed in neocortex, cerebellum, spinal cord and retina where it is expressed by neuronal cells (at protein level) (PubMed:12754272, PubMed:1599432). Detected at much lower level in non-neuronal tissues including kidney, lung, heart, skeletal muscle, spleen and testis (at protein level) (PubMed:12754272, PubMed:1599432). Isoform 1 is more abundant in neocortex and cerebellum compared to isoform 2 (at protein level) (PubMed:12754272) -
Isoforms & Post-Translational Modification
P25686 has two isomers: P25686-3: 35580 Da (predicted); P25686-2: 30569 Da (predicted).
Ubiquitinated by STUB1; does not lead to proteasomal degradation -
Subunit
Interacts with HSP70 (HSPA1A or HSPA1B) (PubMed:21625540, PubMed:22219199)
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SwissProt ID
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Synonyms
CMT2T; DSMA5; HSJ-1; HSJ1; HSPF3
Documentation
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