DR4/TNFRSF10A Antibody (YA7092)

Cat. No.: HY-P87404: Data Sheet User Guide for Antibodies
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DR4/TNFRSF10A Antibody (YA7092) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to DR4/TNFRSF10A.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

DR4/TNFRSF10A Antibody (YA7092) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to DR4/TNFRSF10A.

Host

Rabbit

Clonality

Recombinant

Molecular Weight

Predicted band size: 50kDa;

Species Reactivity

Human

SwissProt ID

O00220

Immunogen

Purified recombinant fragment of human TNFRSF10A (AA: 260-470) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:5000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-200
FC FC: Flow Cytometry	1:1000

Sensitivity	Endogenous	Purity	affinity purified.
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclin 950.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518, PubMed:38532423). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789). Promotes the activation of NF-kappa-B (PubMed:9430227)

Subcellular Localization：Cell membrane,Membrane raft,Cytoplasm, cytosol

Expression：
Tissue_Specificity: Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells

Isoforms & Post-Translational Modification：O00220: 468 amino acids, molecular weight 50089 Da.

Subunit：Monomer (PubMed:26457518)

Database

SwissProt: SwissProt: O00220

Documentation

User Guide for Antibodies (1077 KB)