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Cat. No.: HY-P87404

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DR4/TNFRSF10A Antibody (YA7092)

DR4/TNFRSF10A Antibody (YA7092) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to DR4/TNFRSF10A.

For research use only. We do not sell to patients.

Host:
Rabbit
Isotype:
IgG
Application:
WB, ICC/IF, FC
Reactivity :
Human

Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclin 950.

Conjugation:
Non-conjugated

Price

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Quantity

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications
Product Details
Product Properties
- Appearance
- Formulation
- Storage & Stability
- Shipping
Background
Documentation
Help & FAQs
Classifications
Bioz

Applications

Application	WB WB: Western Blot	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	FC FC: Flow Cytometry
Dilution Ratio	1:5000	1:100-200	1:1000

Product Details

Description

DR4/TNFRSF10A Antibody (YA7092) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to DR4/TNFRSF10A.

Host Rabbit
Clonality Recombinant
Species Reactivity
Human
Calculated Molecular Weight Predicted band size: 50kDa;

Species Reactivity Database

SwissProt: SwissProt: O00220

Immunogen

Purified recombinant fragment of human TNFRSF10A (AA: 260-470) expressed in E. Coli.

Sensitivity

Endogenous

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

Appearance

Liquid
Formulation

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclin 950.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Background

Function

DR4/TNFRSF10A receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B^[1]^[2]^[3]^[4].
Subcellular Localization

Cell membrane,Membrane raft,Cytoplasm, cytosol
Expression

Tissue_Specificity: Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells
Isoforms & Post-Translational Modification

O00220: 468 amino acids, molecular weight 50089 Da.
Subunit

Monomer (PubMed:26457518)
SwissProt ID

O00220