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Cat. No.: HY-P86151

eIF4B Antibody (YA5843)

Name: eIF4B Antibody (YA5843)
Brand: MedChemExpress
SKU: HY-P86151
Availability: PreOrder

(Synonyms: Eukaryotic translation initiation factor 4B; eIF-4B; )

eIF4B Antibody (YA5843) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to eIF4B.

For research use only. We do not sell to patients.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	IHC-P IHC-P: Immunohistochemistry-Paraffin	WB WB: Western Blot	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	ELISA ELISA: Enzyme Linked Immunosorbent Assay	IP IP: Immunoprecipitation
Dilution Ratio	1:200-1:1000	1:2000-1:10000	1:200-1:1000	1:5000-1:20000	1:50-1:200

Description

eIF4B Antibody (YA5843) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to eIF4B.

Host Rabbit
Clonality Monoclonal
Species Reactivity
Human
Observed Molecular Weight

Observed band size: 80 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 69 kDa

Purification

Protein A

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Appearance

Liquid
Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

eIF4B is required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F
Isoforms & Post-Translational Modification

P23588 has 2 isomers: P23588-1: 69151 Da (predicted); P23588-2: 64805 Da (predicted).
Phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1; phosphorylation enhances the affinity of EIF4B for the EIF3 complex. In response to mTORC1 activation, RPS6KA1-mediated phosphorylation at 'Ser-406' and 'Ser-422' stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function
Subunit

Self-associates and interacts with EIF3 p170 subunit
SwissProt ID

P23588
Gene ID

1975 [NCBI]
Synonyms

Eukaryotic translation initiation factor 4B; eIF-4B;