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EIF4B - eukaryotic translation initiation factor 4B Gene

Also Known as EIF-4B; PRO1843

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1975

About EIF4B

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,006,456-53,042,215 (from NCBI)

This gene has 14 transcripts (splice variants), 262 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 285.6), thyroid (RPKM 146.6) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in eukaryotic translation initiation factor 4F complex assembly and formation of translation preinitiation complex. Located in cytosol. Biomarker of autism spectrum disorder and major depressive disorder. [provided by Alliance of Genome Resources, Apr 2022]

EIF4B Products (3)

mRNA	Protein	Name
NM_001300821.3	NP_001287750.1	eukaryotic translation initiation factor 4B isoform 1
NM_001330654.2	NP_001317583.1	eukaryotic translation initiation factor 4B isoform 3
NM_001417.7	NP_001408.2	eukaryotic translation initiation factor 4B isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF4B Protein Structure

RRM_1

0
100
200
300
400
500
611 a.a.

Protein Preferred Names	Protein Names
eukaryotic translation initiation factor 4B

EIF4B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EIF4B	P23588	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	EIF4B	P23588	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	EIF4B	P23588	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	EIF4B	P23588	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	EIF4B	P23588	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
Intra	EIF4B	P23588	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	EIF4B	P23588	PLK1	Homo sapiens	P53350	Protein Kinase Assay	21887822
Intra	EIF4B	P23588	TINF2	Homo sapiens	Q9BSI4	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

EIF4B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80651	eIF4B Antibody (YA464)	WB, IHC-P	Human
HY-P80651A	eIF4B Antibody (YA464)(PBS only)	WB, IHC-P	Human
HY-P810607	Phospho-eIF4B (Ser406) Antibody (YA9869)	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
HY-P810608	Phospho-eIF4B (Ser406) Antibody (YA9870)	WB	Human, Mouse, Rat
HY-P84198	eIF4B Antibody (YA3895)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse
HY-P84198A	eIF4B Antibody (YA3895)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse
HY-P86151	eIF4B Antibody (YA5843)	WB, IHC-P, ICC/IF, IP, ELISA	Human

Related Diseases

Diseases	Alias
Mouth Disease	Mouth Diseases Mouth Disorders
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-129239	Farudodstat		99.68%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04273	EIF4B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17097	Eif4b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23541	Eif4b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EIF4B	RGD	RGD:1306479
Mus musculus	EIF4B	MGD	MGI:95304
Canis familiaris	EIF4B	VGNC	VGNC:40282
Bos taurus	EIF4B	VGNC	VGNC:28407
Felis catus	EIF4B	VGNC	VGNC:61790
Others	EIF4B	NCBI