EIF5A2 Antibody (YA8484)
(Synonyms: EIF-5A2; eIF5AII)EIF5A2 Antibody (YA8484) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to EIF5A2.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 | 1:100 |
Product Details
EIF5A2 Antibody (YA8484) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to EIF5A2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 16.6 kDa
Full length human recombinant protein of human EIF5A2 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
EIF5A2 is a Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step. Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity[1].
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Subcellular Localization
Cytoplasm,Nucleus,Endoplasmic reticulum membrane
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Expression
Tissue_Specificity: Expressed in ovarian and colorectal cancer cell lines (at protein level). Highly expressed in testis. Overexpressed in some cancer cells -
Isoforms & Post-Translational Modification
Q9GZV4: 153 amino acids, molecular weight 16793 Da.
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Subunit
Binds to 80S ribosomes (By similarity)
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SwissProt ID
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Synonyms
EIF-5A2; eIF5AII
Documentation
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