EMG1 Antibody (YA8490)
(Synonyms: C2F; Grcc2f; NEP1)EMG1 Antibody (YA8490) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to EMG1.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
ICC/IF, FC
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Reactivity :
Human, Dog, Monkey, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:100-250 | 1:100 |
Product Details
EMG1 Antibody (YA8490) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to EMG1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Dog, Monkey, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 26.5 kDa
Full length human recombinant protein of human EMG1 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
EMG1 is a S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position. Also has an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome[1][2].
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Subcellular Localization
Nucleus, nucleolus
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Isoforms & Post-Translational Modification
Q92979: 244 amino acids, molecular weight 26720 Da.
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Subunit
Homodimer
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SwissProt ID
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Synonyms
C2F; Grcc2f; NEP1
Documentation
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