FKBP51 Antibody (YA7225)
(Synonyms: AIG6, FKBP51, FKBP5, Peptidyl-prolyl cis-trans isomerase FKBP5, PPIase FKBP5, 51 kDa FK506-binding protein, 54 kDa progesterone receptor-associated immunophilin, Androgen-regulated protein 6, FF1 antigen, FK506-binding protein 5, FKBP54, HSP90-binding immunophilin, Rotamase, 51 kDa FKBP, FKBP-51, FKBP-5, p54)
Based on 1 Customer Validation
FKBP51 Antibody (YA7225) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FKBP51.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IHC-F, IF-Tissue, FC, ICC/IF
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Reactivity :
Human, Rat
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Formulation:
Supplied in 0.01M tris buffered saline (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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FC
FC: Flow Cytometry
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:100-500 | 1:100-500 | 1:100-500 | 1:50-100 | 1:50-200 |
Product Details
FKBP51 Antibody (YA7225) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FKBP51.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Rat Predicted Reactivity: Human,Rat
Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
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Observed Molecular WeightObserved band size: 50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 51 kDa
KLH conjugated synthetic peptide derived from human FKBP51
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 0.01M tris buffered saline (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
FKBP51, encoded by FKBP5, is an Hsp90-associated immunophilin co-chaperone that regulates glucocorticoid receptor sensitivity and steroid receptor signaling[1]. Mechanistically, FKBP51 integrates into GR:Hsp90 complexes and antagonizes FKBP52-dependent potentiation of glucocorticoid receptor activity[2]. In cancer signaling models, FKBP51 acts as an Akt-PHLPP scaffold and promotes Akt dephosphorylation, linking FKBP51 biology to chemotherapy response research[3]. In stress-related disease studies, FKBP5 polymorphisms associate with antidepressant response, depressive episode recurrence, and childhood-abuse-dependent PTSD symptom risk[4][5]. Compared with FKBP52, FKBP51 remains a key isoform because selective ligand design must overcome their conserved FK1 binding domains and opposing GR functions[2][6]. For experimental applications, SAFit1 and SAFit2 provide selective FKBP51 inhibition through induced fit, supporting isoform-focused studies of stress behavior, neuroendocrine feedback, and target engagement[6][7].- FKBP51 research should prioritize GR:Hsp90 regulation, FKBP52 contrast, and stress-related experimental models. - SAFit-class inhibitors enable isoform-selective FKBP51 perturbation but require careful probe validation.
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Subcellular Localization
Cytoplasm,Nucleus
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Expression
Tissue_Specificity: Widely expressed, enriched in testis compared to other tissues
Induction: By androgen -
Isoforms & Post-Translational Modification
Q13451 has two isomers: Q13451-1: 51212 Da (predicted); Q13451-2: 30032 Da (predicted).
Acetylation impairs ability to promote interaction between Akt/AKT1 and PHLPP1 (PubMed:28147277)丨Ubiquitinated, leading to degradation in a proteasome-dependent manner -
Subunit
Part of a heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B and steroid receptors
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SwissProt ID
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Synonyms
AIG6, FKBP51, FKBP5, Peptidyl-prolyl cis-trans isomerase FKBP5, PPIase FKBP5, 51 kDa FK506-binding protein, 54 kDa progesterone receptor-associated immunophilin, Androgen-regulated protein 6, FF1 antigen, FK506-binding protein 5, FKBP54, HSP90-binding immunophilin, Rotamase, 51 kDa FKBP, FKBP-51, FKBP-5, p54
Documentation
References
[1]. Storer CL, et al. FKBP51 and FKBP52 in signaling and disease. Trends Endocrinol Metab. 2011 Dec;22(12):481-90. [Content Brief]
[2]. Noddings CM, et al. Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor. Nat Struct Mol Biol. 2023 Dec;30(12):1867-1877. [Content Brief]
[3]. Pei H, et al. FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell. 2009 Sep 8;16(3):259-66. [Content Brief]
[4]. Binder EB, et al. Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nat Genet. 2004 Dec;36(12):1319-25. [Content Brief]
[5]. Binder EB, et al. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA. 2008 Mar 19;299(11):1291-305. [Content Brief]
[6]. Gaali S, et al. Selective inhibitors of the FK506-binding protein 51 by induced fit. Nat Chem Biol. 2015 Jan;11(1):33-7. [Content Brief]
[7]. Buffa V, et al. Analysis of the Selective Antagonist SAFit2 as a Chemical Probe for the FK506-Binding Protein 51. ACS Pharmacol Transl Sci. 2023 Feb 14;6(3):361-371. [Content Brief]
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